A successful treatment approach in 2 patients with type 1 plasminogen deficiency: Intratracheal application of fresh frozen plasma and tissue plasminogen activator

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dc.authorid0000-0003-4292-1409
dc.contributor.authorAl, Serdar
dc.contributor.authorUlusoy, Oktay
dc.contributor.authorAsilsoy, Suna
dc.contributor.authorUzuner, Nevin
dc.contributor.authorKangallı, Özge
dc.contributor.authorAtay, Özge
dc.contributor.authorOdaman Al, Işık
dc.contributor.authorAteş, Oğuz
dc.date.accessioned2023-10-06T11:24:34Z
dc.date.available2023-10-06T11:24:34Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractBACKGROUND: Respiratory system involvement is common in congenital plasminogen deficiency. Although many treatment approaches have been tried, there is still no definitive treatment for respiratory system involvement. OBSERVATIONS: We report 2 congenital plasminogen deficiency cases, who presented with severe respiratory symptoms, for whom a novel treatment modality was tried. After intravenous administration of FFP (fresh frozen plasma), tissue plasminogen activator and FFP were administered intratracheally, and respiratory system findings improved. CONCLUSIONS: Intratracheal administration of tissue plasminogen activator and FFP is an available treatment modality for patients with lung involvement. Fibrin plaques should be carefully removed and new lesion formation should be prevented.
dc.identifier.citationAl, S., Ulusoy, O., Asilsoy, S., Uzuner, N., Kangallı, Ö., Atay, Ö. ... Ateş, O. (2023). A successful treatment approach in 2 patients with type 1 plasminogen deficiency: Intratracheal application of fresh frozen plasma and tissue plasminogen activator. Journal of Pediatric Hematology/Oncology, 45(7), 423-426. https://doi.org/10.1097/MPH.0000000000002698
dc.identifier.doi10.1097/MPH.0000000000002698
dc.identifier.endpage426
dc.identifier.issn1536-3678
dc.identifier.issn1077-4114
dc.identifier.issue7
dc.identifier.pmid37490638
dc.identifier.scopus2-s2.0-85172711537
dc.identifier.scopusqualityQ3
dc.identifier.startpage423
dc.identifier.urihttps://doi.org/10.1097/MPH.0000000000002698
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11536
dc.identifier.volume45
dc.identifier.wos001156976000006en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorOdaman Al, Işık
dc.language.isoen
dc.publisherNLM (Medline)
dc.relation.ispartofJournal of Pediatric Hematology/Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectPlasminogen Deficiency
dc.subjectPlasminogen
dc.subjectFresh Frozen Plasma
dc.subjectPseudomembranes
dc.subjectRespiratory System
dc.subjectCongenital
dc.titleA successful treatment approach in 2 patients with type 1 plasminogen deficiency: Intratracheal application of fresh frozen plasma and tissue plasminogen activator
dc.typeArticle

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