Different epidemiology of bloodstream infections in COVID-19 compared to non-COVID-19 critically ill patients: A descriptive analysis of the Eurobact II study

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dc.authorid0000-0002-5715-8138
dc.contributor.authorBuetti, Niccolò
dc.contributor.authorTabah, Alexis
dc.contributor.authorLoiodice, Ambre
dc.contributor.authorRuckly, Stéphane
dc.contributor.authorAslan, Abdullah Tarık
dc.contributor.authorMontrucchio, Giorgia
dc.contributor.authorCortegiani, Andrea
dc.contributor.authorSaltoğlu, Neşe
dc.contributor.authorKayaaslan, Bircan
dc.contributor.authorAksoy, Firdevs
dc.contributor.authorMurat, Akova
dc.contributor.authorAkdoğan, Özlem
dc.contributor.authorSaraçoğlu, Kemal Tolga
dc.contributor.authorErdoğan, Cem
dc.contributor.authorLeone, Marc
dc.contributor.authorFerrer, Ricard
dc.contributor.authorPaiva, José-Artur
dc.contributor.authorHayashi, Yoshiro
dc.contributor.authorRamanan, Mahesh
dc.contributor.authorConway Morris, Andrew
dc.contributor.authorBarbier, François
dc.contributor.authorTimsit, Jean-François
dc.contributor.authorLipman, Jeffrey
dc.contributor.authorLitton, Edward
dc.contributor.authorPalermo, Anna Maria
dc.contributor.authorYap, Timothy
dc.contributor.authorEroğlu, Ege
dc.contributor.authorHosokawa, Koji
dc.contributor.authorYoshida, Hideki
dc.contributor.authorFujitani, Shigeki
dc.contributor.authorZand, Farid
dc.contributor.authorMahmoodpoor, Ata
dc.contributor.authorTabatabaei, Seyed Mohammad Nasirodin
dc.contributor.authorElrabi, Omar
dc.contributor.authorAlmekhlafi, Ghaleb A.
dc.contributor.authorVidal, Gabriela
dc.contributor.authorAparicio, Marta
dc.contributor.authorAlonzo, Irene
dc.contributor.authorNamendys-Silva, Silvio A.
dc.contributor.authorHermosillo, Mariana
dc.contributor.authorCastillo, Roberto Alejandro
dc.contributor.authorDe Bus, Liesbet
dc.contributor.authorDe Waele, Jan
dc.contributor.authorHollevoet, Isabelle
dc.contributor.authorDe Schryver, Nicolas
dc.contributor.authorSerck, Nicolas
dc.contributor.authorKovacevic, Pedja
dc.contributor.authorZlojutro, Biljana
dc.contributor.authorRuppe, Etienne
dc.contributor.authorMontravers, Philippe
dc.contributor.authorDulac, Thierry
dc.contributor.authorCastanera, Jérémy
dc.contributor.authorMassri, Alexandre
dc.contributor.authorGuesdon, Charlotte
dc.contributor.authorGarcon, Pierre
dc.contributor.authorDuprey, Matthieu
dc.contributor.authorPhilippart, François
dc.contributor.authorTran, Marc
dc.contributor.authorBruel, Cédric
dc.contributor.authorKalfon, Pierre
dc.date.accessioned2022-10-31T06:38:31Z
dc.date.available2022-10-31T06:38:31Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı
dc.description.abstractBackground: The study aimed to describe the epidemiology and outcomes of hospital-acquired bloodstream infections (HABSIs) between COVID-19 and non-COVID-19 critically ill patients. Methods: We used data from the Eurobact II study, a prospective observational multicontinental cohort study on HABSI treated in ICU. For the current analysis, we selected centers that included both COVID-19 and non-COVID-19 critically ill patients. We performed descriptive statistics between COVID-19 and non-COVID-19 in terms of patients’ characteristics, source of infection and microorganism distribution. We studied the association between COVID-19 status and mortality using multivariable fragility Cox models. Results: A total of 53 centers from 19 countries over the 5 continents were eligible. Overall, 829 patients (median age 65 years [IQR 55; 74]; male, n = 538 [64.9%]) were treated for a HABSI. Included patients comprised 252 (30.4%) COVID-19 and 577 (69.6%) non-COVID-19 patients. The time interval between hospital admission and HABSI was similar between both groups. Respiratory sources (40.1 vs. 26.0%, p < 0.0001) and primary HABSI (25.4% vs. 17.2%, p = 0.006) were more frequent in COVID-19 patients. COVID-19 patients had more often enterococcal (20.5% vs. 9%) and Acinetobacter spp. (18.8% vs. 13.6%) HABSIs. Bacteremic COVID-19 patients had an increased mortality hazard ratio (HR) versus non-COVID-19 patients (HR 1.91, 95% CI 1.49–2.45). Conclusions: We showed that the epidemiology of HABSI differed between COVID-19 and non-COVID-19 patients. Enterococcal HABSI predominated in COVID-19 patients. COVID-19 patients with HABSI had elevated risk of mortality. Trial registration ClinicalTrials.org number NCT03937245. Registered 3 May 2019.
dc.identifier.citationBuetti, N., Tabah, A., Loiodice, A., Ruckly, S., Aslan, A. T., Montrucchio, G. ... Kalfon, P. (2022). Different epidemiology of bloodstream infections in COVID-19 compared to non-COVID-19 critically ill patients: A descriptive analysis of the Eurobact II study. Critical Care, 26(1). https://doi.org/10.1186/s13054-022-04166-y
dc.identifier.doi10.1186/s13054-022-04166-y
dc.identifier.issn1364-8535
dc.identifier.issn1466-609X
dc.identifier.issue1
dc.identifier.pmid36258239
dc.identifier.scopus2-s2.0-85140066700
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1186/s13054-022-04166-y
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9890
dc.identifier.volume26
dc.identifier.wos000869836500007en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErdoğan, Cem
dc.language.isoen
dc.publisherBioMed Central Ltd
dc.relation.ispartofCritical Careen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectBacteremia
dc.subjectBloodstream Infection
dc.subjectCOVID-19
dc.subjectEnterococcus
dc.subjectICU-Acquired
dc.titleDifferent epidemiology of bloodstream infections in COVID-19 compared to non-COVID-19 critically ill patients: A descriptive analysis of the Eurobact II study
dc.typeArticle

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