Epidemiological trends and clinical features of the ongoing monkeypox epidemic: A preliminary pooled data analysis and literature review

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dc.authorid0000-0002-7919-1326
dc.contributor.authorBragazzi, Nicola L.
dc.contributor.authorKong, Jude D.
dc.contributor.authorMahroum, Naim
dc.contributor.authorTsigalou, Christina
dc.contributor.authorKhamisy-Farah, Rola
dc.contributor.authorConverti, Manlio
dc.contributor.authorWu, Jianhong
dc.date.accessioned2023-02-22T08:57:51Z
dc.date.available2023-02-22T08:57:51Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractAn emerging outbreak of monkeypox infection is quickly spreading worldwide, being currently reported in more than 30 countries, with slightly less than 1000 cases. In the present preliminary report, we collected and synthesized early data concerning epidemiological trends and clinical features of the ongoing outbreak and we compared them with those of previous outbreaks. Data were pooled from six clusters in Italy, Australia, the Czech Republic, Portugal, and the United Kingdom, totaling 124 cases (for 35 of which it was possible to retrieve detailed information). The ongoing epidemic differs from previous outbreaks in terms of age (54.29% of individuals in their thirties), sex/gender (most cases being males), risk factors, and transmission route, with sexual transmission being highly likely. Also, the clinical presentation is atypical and unusual, being characterized by anogenital lesions and rashes that relatively spare the face and extremities. The most prevalent sign/symptom reported was fever (in 54.29% of cases) followed by inguinal lymphadenopathy (45.71%) and exanthema (40.00%). Asthenia, fatigue, and headache were described in 22.86% and 25.71% of the subjects, respectively. Myalgia was present in 17.14% of the cases. Both genital and anal lesions (ulcers and vesicles) were reported in 31.43% of the cases. Finally, cervical lymphadenopathy was described in 11.43% of the sample, while the least commonly reported symptoms were diarrhea and axillary lymphadenopathy (5.71% of the case series for both symptoms). Some preliminary risk factors can be identified (being a young male, having sex with other men, engaging in risky behaviors and activities, including condomless sex, human immunodeficiency virus positivity (54.29% of the sample analyzed), and a story of previous sexually transmitted infections, including syphilis). On the other hand, being fully virally suppressed and undetectable may protect against a more severe infectious course. However, further research in the field is urgently needed.
dc.identifier.citationBragazzi, Nicola L., Kong, Jude D., Mahroum, N., Tsigalou, C., Khamisy-Farah, R., Converti, M. ... Wu, J. (2023). Epidemiological trends and clinical features of the ongoing monkeypox epidemic: A preliminary pooled data analysis and literature review. Journal of Medical Virology, 95(1). https://doi.org/10.1002/jmv.27931
dc.identifier.doi10.1002/jmv.27931
dc.identifier.issn0146-6615
dc.identifier.issn1096-9071
dc.identifier.issue1
dc.identifier.pmid35692117
dc.identifier.scopus2-s2.0-85131920094
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/jmv.27931
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10502
dc.identifier.volume95
dc.identifier.wos000812187500001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMahroum, Naim
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Medical Virologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectEmerging Pathogen
dc.subjectMonkeypox
dc.subjectOutbreak
dc.subjectPooled Data Analysis
dc.titleEpidemiological trends and clinical features of the ongoing monkeypox epidemic: A preliminary pooled data analysis and literature review
dc.typeArticle

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