Premature progesterone elevation does not affect pregnancy outcome in high-responder patients undergoing short-interval coasting in IVF cycles

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dc.contributor.authorAcet, Mustafa
dc.contributor.authorAktün, Lebriz Hale
dc.contributor.authorBaşarano?lu, Serdar
dc.contributor.authorYorgunlar, Betül
dc.contributor.authorAcet, Tuba
dc.contributor.authorDeregözü, Ayşegül
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:44Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:44Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.descriptionWOS: 000399157000040
dc.descriptionPubMed ID: 26634938
dc.description.abstractBackground: We aimed to present the relationship between premature progesterone elevation (PPE) and clinical outcomes in high-responder patients who had a coasting period of < 4 days in length due to their high risk of developing ovarian hyperstimulation syndrome (OHSS) and who were treated with a long-acting gonadotropin-releasing hormone agonist (GnRH-agonist) protocol in in vitro fertilization-embryo transfer (IVF-ET) cycles. Material/Methods: This retrospective study was conducted at the University Hospital Assisted Reproductive Technology Center. The outcomes of 101 patients undergoing IVF-intracytoplasmic sperm injection (ICSI) cycles who showed a high response to COH (estradiol > 4000 pg/ml and/or > 20 follicles each >= 10 mm in diameter and at least 20% 3 15 mm) and who were coasted for < 4 days were evaluated. Number of oocytes, 2 pronuclei (PN) embryos, implantation rate, and live birth rate were measured. Results: The incidence of PPE was 32.6%. Compared with those without PPE, patients with PPE had a higher number of oocytes retrieved. Total mature and fertilized oocytes and the mean number of embryos transferred were not significantly different between groups. Live birth rates (41.9% vs. 38.7%) and implantation rates (26.5% vs. 23%) were also not significantly divergent in the PPE and non-PPE groups, respectively. Conclusions: P concentrations >= 1.3 ng/ml on the day of human chorionic gonadotropin (hCG) administration, designated in this study as PPE, does not appear to be related to adverse effects in terms of clinical outcomes in high-responder patients undergoing coasting < 4 days due to their high risk of developing OHSS treated with a long-acting GnRH-a protocol in IVF-embryo transfer cycles.
dc.identifier.citationAcet, M., Aktün, L. H., Başarano?lu, S., Yorgunlar, B., Acet, T. ve Deregözü, A. (2015). Premature progesterone elevation does not affect pregnancy outcome in high-responder patients undergoing short-interval coasting in IVF cycles. Medical Science Monitor Basic Research, 21, 247-252. https://dx.doi.org/10.12659/MSMBR.896244
dc.identifier.doi10.12659/MSMBR.896244
dc.identifier.endpage252
dc.identifier.issn2325-4416
dc.identifier.issn2325-4394
dc.identifier.scopusqualityQ2
dc.identifier.startpage247
dc.identifier.urihttps://dx.doi.org/10.12659/MSMBR.896244
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3424
dc.identifier.volume21
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInternational Scientific Literature
dc.relation.ispartofMedical Science Monitor Basic Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Unported*
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/*
dc.subjectFertilization In Vitro
dc.subjectGonadotropin-Releasing Hormone
dc.subjectPregnancy Rate
dc.subjectProgesterone
dc.titlePremature progesterone elevation does not affect pregnancy outcome in high-responder patients undergoing short-interval coasting in IVF cycles
dc.typeArticle

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