Effects of vincamine on testicular dysfunction in alloxan-induced diabetic male rats

Parlar Köprülü, Rabia Edibe; Okur, Mehmet Evren; Kolbaşı, Bircan; Keskin, İlknur; Özbek, Hanefi

Effects of vincamine on testicular dysfunction in alloxan-induced diabetic male rats

dc.authorid	0000-0003-0052-3648
dc.authorid	0000-0001-7933-4262
dc.authorid	0000-0002-7059-1884
dc.contributor.author	Parlar Köprülü, Rabia Edibe
dc.contributor.author	Okur, Mehmet Evren
dc.contributor.author	Kolbaşı, Bircan
dc.contributor.author	Keskin, İlknur
dc.contributor.author	Özbek, Hanefi
dc.date.accessioned	2023-07-13T06:42:47Z
dc.date.available	2023-07-13T06:42:47Z
dc.date.issued	2022
dc.department	İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.department	İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstract	Background: Diabetes mellitus (DM) is frequently linked with problems of several organ systems, including retinopathy, neuropathy, and nephropathy. Additionally, patients have changes in sexual functioning, such as decreased libido and fertility. Vincamine, a monoterpenoid indole alkaloid, has hypoglycemic and antioxidant effects. Objectives: This research assessed the impact of vincamine on testicular dysfunction in alloxan-induced male rats by measuring fasting blood glucose, oxidative stress, seminal analysis, and histological examination of the testis. Methods: Wister-albino male rats were randomized into the following groups at random: Untreated-healthy, untreated-DM, vincamine-treated (20 mg/kg) DM, vincamine-treated (40 mg/kg) DM, and clomiphene-treated DM (5 mg/kg). On day 14, rats were sacrificed, and semen/blood samples were collected. Sperm count, motility, and morphological abnormalities were noted by microscopic examination. The testis was examined histopathologically and assessed using Johnsen’s score. Results: Compared with the untreated diabetic group, a dosage of 40 mg/kg vincamine generate a significant reduction in fasting blood sugar (FBG). Compared with the untreated diabetic group, the vincamine-treated rats produced greater plasma testosterone levels and Johnsen scores. In the vincamine 20 mg/kg group, sperm concentration was higher than in the vincamine 40 mg/kg group. Conclusions: It is possible that vincamine has a potential preventive effect against diabetes-related reproductive problems attributable to its antioxidant activity and capacity to restore testicular steroidogenesis.
dc.identifier.citation	Parlar Köprülü, R. E., Okur, M. E., Kolbaşı, B., Keskin, İ. ve Özbek, H. (2022). Effects of vincamine on testicular dysfunction in alloxan-induced diabetic male rats. Iranian Journal of Pharmaceutical Research, 21(1). https://dx.doi.org/10.5812/ijpr-132265
dc.identifier.doi	10.5812/ijpr-132265
dc.identifier.issn	1735-0328
dc.identifier.issn	1726-6890
dc.identifier.issue	1
dc.identifier.pmid	36942057
dc.identifier.scopus	2-s2.0-85147303339
dc.identifier.scopusquality	Q2
dc.identifier.uri	https://dx.doi.org/10.5812/ijpr-132265
dc.identifier.uri	https://hdl.handle.net/20.500.12511/11190
dc.identifier.volume	21
dc.identifier.wos	001016337500001	en_US
dc.identifier.wosquality	Q4
dc.indekslendigikaynak	Web of Science
dc.indekslendigikaynak	Scopus
dc.indekslendigikaynak	PubMed
dc.institutionauthor	Parlar Köprülü, Rabia Edibe
dc.institutionauthor	Kolbaşı, Bircan
dc.institutionauthor	Keskin, İlknur
dc.language.iso	en
dc.publisher	Brieflands
dc.relation.ispartof	Iranian Journal of Pharmaceutical Research	en_US
dc.relation.publicationcategory	Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rights	Attribution-NonCommercial 4.0 International	*
dc.rights	info:eu-repo/semantics/openAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc/4.0/	*
dc.subject	Testis
dc.subject	Testosterone
dc.subject	Spermatogenesis
dc.subject	Rat
dc.subject	Diabetes Mellitus
dc.title	Effects of vincamine on testicular dysfunction in alloxan-induced diabetic male rats
dc.type	Article