Female gender specific association of the Reelin (RELN) gene rs7341475 variant with schizophrenia

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dc.contributor.authorSözügüzel, Mavi Deniz
dc.contributor.authorSazcı, Ali
dc.contributor.authorYıldız, Mustafa
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:32Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:32Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.descriptionWOS: 000470332600078
dc.descriptionPubMed ID: 30980267
dc.description.abstractRELN gene encodes a large extracellular matrix protein which is critical for neuronal migration, cell positioning and cell-cell interactions. It also controls the synaptic plasticity of neurons for initiation and maintenance of long term potentiation. The aim of this study is to investigate the association of RELN rs7341475 variant with schizophrenia. Genomic DNA isolation was performed from 105 schizophrenic patients and 137 healthy controls to determine RELN rs7341475 genotypes. Genotype and allele frequencies were determined by a polymerase chain reaction-restriction fragment length polymorphism method developed in our laboratory. Statistical analysis was performed using (2) test. The frequencies for G allele were 79.5% in cases and 81.0% in controls, for A allele 20.5% in cases and 19.0% in controls in the overall population. The genotype frequencies of the RELN gene rs7341475 variant were GG; 63.8%, GA; 31.4% and AA; 4.8% in cases, GG; 63.5%, GA; 35.0% and AA; 1.5% in controls in the overall population. There was no statistically significant association between the rs7341475 variant of RELN gene and schizophrenia in the overall population ((2)=2.473, p=0.290). In the gender specific analysis, female gender specific association was only found. The RELN rs7341475 variant GG genotype was significantly associated with schizophrenia (p=0.034, OR 2.760, 95% CI 1.058-7.197) and A allele was protective against schizophrenia (p=0.034, OR 0.362, 95% CI 0.139-0.945). All cases and controls were in Hardy-Weinberg equilibrium (p>0.05). Population size can be increased to improve the statistical power. Moreover, other RELN gene variants which are especially involved in neuronal migration and epigenetic regulation may be analyzed for revealing the complex genetic architecture of schizophrenia. In conclusion, there was only association between the RELN rs7341475 variant and schizophrenia in the female gender in a Turkish population.
dc.description.sponsorshipKocaeli University [2011/68]en_US
dc.description.sponsorshipThis study was supported by Kocaeli University, Project No: 2011/68 to AS.en_US
dc.identifier.citationSözügüzel, M. D., Sazcı, A. ve Yıldız, M. (2019). Female gender specific association of the Reelin (RELN) gene rs7341475 variant with schizophrenia. Molecular Biology Reports, 46(3), 3411-3416. https://dx.doi.org/10.1007/s11033-019-04803-w
dc.identifier.doi10.1007/s11033-019-04803-w
dc.identifier.endpage3416
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue3
dc.identifier.scopusqualityQ2
dc.identifier.startpage3411
dc.identifier.urihttps://dx.doi.org/10.1007/s11033-019-04803-w
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1636
dc.identifier.volume46
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofMolecular Biology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRELN Gene
dc.subjectSchizophrenia
dc.subjectPolymorphism
dc.subjectrs7341475
dc.subjectFemale Gender
dc.subjectSpecific Association
dc.subjectTurkish Population
dc.titleFemale gender specific association of the Reelin (RELN) gene rs7341475 variant with schizophrenia
dc.typeArticle

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