Diagnosing latent tuberculosis in immunocompromised patients measuring blood IP-10 production capacity: An analysis of chronic renal failure patients

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dc.authorid0000-0001-6639-2797
dc.contributor.authorSeyhan, Ekrem
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:51:07Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:51:07Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000366134400111
dc.description.abstractPURPOSE: Patients undergoing haemodialysis for chronic renal failure (CRF-HD) are at risk of latent tuberculosis infection (LTBI). The effectiveness of using blood IP-10 production capacity to diagnose LTBI in CRF-HD patients was analysed. METHODS: The study enrolled 50 CRF-HD patients. Interferon-gamma release assay (IGRA) was done using Quantiferon G-In-Tube (QFG-IT) system. Blood IP-10 production capacity was measured using the QFG-IT system tubes. Tuberculin skin testing (TST) was performed on the same day and the test results were compared. RESULTS: TST turned out to be positive in 36.4% of the patients and QFG-IT in 54% of them. After stimulation with specific tuberculosis antigens, blood IP-10 levels increased noticeably. The antigen-stimulated blood IP-10 level was significantly higher in patients who were either TST or QFG-IT positive than in patients whose tests were negative (p=0.0001). Using 4.02 pg/mL as the threshold for stimulated blood log-transformed IP-10 level, good agreement was observed between IP-10 and QFG-IT results (?=1). CONCLUSIONS: Blood IP-10 level, which can be measured simply, provides results equivalent to interferon-? release assays for the diagnosis of LTBI in CRF-HD patients.
dc.identifier.citationSeyhan, E. (2015). Diagnosing Latent Tuberculosis in Immunocompromised Patients Measuring Blood IP-10 Production Capacity: An Analysis of Chronic Renal Failure Patients. Chest, 148(4). https://dx.doi.org/10.1378/chest.2278323
dc.identifier.doi10.1378/chest.2278323
dc.identifier.issn0012-3692
dc.identifier.issue4
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.1378/chest.2278323
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2151
dc.identifier.volume148
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAmerican College of Chest Physicians
dc.relation.ispartofChesten_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectDiagnosing
dc.subjectTuberculosis
dc.subjectMeasuring Blood
dc.titleDiagnosing latent tuberculosis in immunocompromised patients measuring blood IP-10 production capacity: An analysis of chronic renal failure patients
dc.typeConference Object

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