Preliminary study on the impact of 900 MHz radiation on human sperm: an in vitro molecular approach

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dc.contributor.authorKeskin, İlknur
dc.contributor.authorKarabulut, Seda
dc.contributor.authorKaplan, Arife Ahsen
dc.contributor.authorAlagöz, Murat
dc.contributor.authorAkdeniz, Muhterem
dc.contributor.authorTüfekçi, Kıymet Kübra
dc.contributor.authorKaplan, Süleyman
dc.date.accessioned2025-10-27T09:59:40Z
dc.date.available2025-10-27T09:59:40Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Tıbbi Araştırma Merkezi (MEDİTAM)
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractThe use of technologies that produce and emit electromagnetic fields (EMF) is growing exponentially worldwide. The biological effects of EMF-emitting equipment, such as mobile phones and other wireless devices, have been studied in the last decade using in vitro and in vivo methods. Infertility is a growing health problem, and nearly half of cases are because of male-factor. This study investigated the direct in vitro effects of 900 MHz radiation exposure on sperm parameters, genetic status, apoptotic markers, and the PI3K/AKT signaling pathway in healthy normozoospermic men. Semen samples were divided into four groups, two control (30 min and 1 h) and two EMF exposure (30 min and 1 h). Sperm parameters (motility, progressive motility, acrosomal index, morphology), genetic status (DNA fragmentation and chromatin integrity), apoptotic markers (cytokine-c and caspase-3 expression) and the PI3K/AKT signaling pathway (phosphoinoitide 3-kinase-PI3K- and phosphorylated AKT- p-AKT-) were analysed. Sperm motility were significantly reduced in 30 min EMF exposure while a significant increase in the expression of p-AKT were observed in 1 h EMF exposure group. An increased vacuolisation, acrosomal defect, extension of subacrosomal space, uncondensed chromatin structure, apoptotic signs and disrupted axoneme were observed in both EMF groups which were not observed in the control group. Other sperm parameters (morphology and acrosomal index), genetic status, apoptotic markers and the PI3K expression rates had no significant change.
dc.identifier.citationKeskin, İ., Karabulut, S., Kaplan, A. A., Alagöz, M., Akdeniz, M., Tüfekçi, K. K. ... Kaplan, S. (2024). Preliminary study on the impact of 900 MHz radiation on human sperm: an in vitro molecular approach. Reproductive Toxicology, 130. http://dx.doi.org/10.1016/j.reprotox.2024.108744
dc.identifier.doi10.1016/j.reprotox.2024.108744
dc.identifier.issn0890-6238
dc.identifier.issn1873-1708
dc.identifier.pmid39505052
dc.identifier.scopus2-s2.0-85208106536
dc.identifier.scopusqualityQ2
dc.identifier.urihttp://dx.doi.org/10.1016/j.reprotox.2024.108744
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13148
dc.identifier.volume130
dc.identifier.wosWOS:001352809400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKeskin, İlknur
dc.institutionauthorKarabulut, Seda
dc.institutionauthorid0000-0002-7059-1884
dc.institutionauthorid0000-0003-3302-5004
dc.language.isoen
dc.relation.ispartofReproductive Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectApoptosis
dc.subjectMale Fertility
dc.subjectPI3K
dc.subjectSperm Parameters
dc.titlePreliminary study on the impact of 900 MHz radiation on human sperm: an in vitro molecular approach
dc.typeArticle

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