A highly bioavailable curcumin formulation ameliorates inflammation cytokines and neurotrophic factors in mice with traumatic brain injury

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dc.authorid0000-0002-9354-0000
dc.authorid0000-0002-6637-9944
dc.contributor.authorŞakul, Ayşe Arzu
dc.contributor.authorBalçıkanlı, Zeynep
dc.contributor.authorAteş Özsoy, Nilay
dc.contributor.authorOrhan, Cemal
dc.contributor.authorŞahin, Nurhan
dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorJuturu, Vijaya
dc.contributor.authorKılıç, Ertuğrul
dc.contributor.authorŞahin, Kazım
dc.date.accessioned2024-01-16T07:09:00Z
dc.date.available2024-01-16T07:09:00Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractA novel curcumin formulation increases relative absorption by 46 times (CurcuWIN®) of the total curcuminoids over the unformulated standard curcumin form. However, the exact mechanisms by which curcumin demonstrates its neuroprotective effects are not fully understood. This study aimed to investigate the impact of a novel formulation of curcumin on the expression of brain-derived neurotrophic factor (BDNF), glial fibrillary acidic protein (GFAP), a main component of the glial scar and growth-associated protein-43 (GAP-43), a signaling molecule in traumatic brain injury (TBI). Mice (adult, male, C57BL/6j) were randomly divided into three groups as follows: TBI group (TBI-induced mice); TBI + CUR group (TBI mice were injected i.p. curcumin just after TBI); TBI+ CurcuWIN® group (TBI mice were injected i.p. CurcuWIN® just after TBI). Brain injury was induced using a cold injury model. Injured brain tissue was stained with Cresyl violet to evaluate infarct volume and brain swelling, analyzed, and measured using ImageJ by Bethesda (MD, USA). Western blot analysis was performed to determine the protein levels related to injury. While standard curcumin significantly reduced brain injury, CurcuWIN® showed an even greater reduction associated with reductions in glial activation, NF-?B, and the inflammatory cytokines IL-1? and IL-6. Additionally, both standard curcumin and CurcuWIN® led to increased BDNF, GAP-43, ICAM-1, and Nrf2 expression. Notably, CurcuWIN® enhanced their expression more than standard curcumin. This data suggests that highly bioavailable curcumin formulation has a beneficial effect on the traumatic brain in mice.
dc.description.sponsorshipOmniActive Health Technologies ; OmniActive Health Technologies Ltd ; Turkish Academy of Sciencesen_US
dc.identifier.citationŞakul, A. A., Balçıkanlı, Z., Ateş Özsoy, N., Orhan, C., Şahin, N., Tuzcu, M. ... Şahin, K. (2024). A highly bioavailable curcumin formulation ameliorates inflammation cytokines and neurotrophic factors in mice with traumatic brain injury. Chemical Biology and Drug Design, 103(1). https://dx.doi.org/10.1111/cbdd.14439
dc.identifier.doi10.1111/cbdd.14439
dc.identifier.issn1747-0277
dc.identifier.issn1747-0285
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85181484993
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://dx.doi.org/10.1111/cbdd.14439
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12145
dc.identifier.volume103
dc.identifier.wos001134704000001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorŞakul, Ayşe Arzu
dc.institutionauthorAteş Özsoy, Nilay
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofChemical Biology and Drug Designen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCurcumin
dc.subjectInflammation
dc.subjectNeurotrophic Factor
dc.subjectTraumatic Brain Injury
dc.titleA highly bioavailable curcumin formulation ameliorates inflammation cytokines and neurotrophic factors in mice with traumatic brain injury
dc.typeArticle

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