Gingipain injection affects intestinal oxidant-antioxidant status and alkaline phosphatase in overfed zebrafish

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dc.authorid0000-0002-6274-801X
dc.contributor.authorGündüz, Gizem
dc.contributor.authorBeler, Merih
dc.contributor.authorÜnal, İsmail
dc.contributor.authorCansız, Derya
dc.contributor.authorEmekli Alturfan, Ebru
dc.contributor.authorKöse, Kemal Naci
dc.date.accessioned2023-10-24T09:35:30Z
dc.date.available2023-10-24T09:35:30Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractObjective: Porphyromonas gingivalis (P. gingivalis), a major periodontopathogen, is associated with overfeeding disorders, including metabolic syndrome. Gingipains are one of the most powerful endotoxins of P. gingivalis. Our aim was to reveal the effects of gingipain injections on the intestinal oxidant-antioxidant status and alkaline phosphatase (ALP) activity in overfed zebrafish. Materials and Methods: Four groups of healthy adult zebrafish were placed in random tanks as C: Control (n=15); GP: Gingipain (n=15); OF: Overfeeding (n=15); and OF+GP: Overfeeding+Gingipain (n=15) groups. At the end of the experiment, levels of intestinal lipid peroxidation (LPO) and ALP, glutathione S-transferase (GST), and catalase (CAT) activities were evaluated. Results: Intestinal LPO was significantly lower in the GP and OF groups compared to C. Gingipain injection in OF (OF+GP) significantly elevated LPO when compared to C, GP, and OF groups. ALP activities decreased significantly in the GP, OF, and OF+GP compared to C. GST activities increased significantly in the GP when compared to C. Decreased GST activities were observed in the OF and OF+GP. This decrease was less in OF+GP. CAT activities significantly decreased in all groups when compared to C. Conclusion: Our findings demonstrate that gingipain injection alters the ALP activity and intestinal oxidant-antioxidant status in overfed zebrafish.
dc.description.sponsorshipMarmara University
dc.identifier.citationGündüz, G., Beler, M., Ünal, İ., Cansız, D., Emekli Alturfan, E. ve Köse, K. N. (2023). Gingipain injection affects intestinal oxidant-antioxidant status and alkaline phosphatase in overfed zebrafish. Experimed, 13(2), 80-85. https://doi.org/10.26650/experimed.1268503
dc.identifier.doi10.26650/experimed.1268503
dc.identifier.endpage85
dc.identifier.issn2667-5846
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85173733638
dc.identifier.scopusqualityN/A
dc.identifier.startpage80
dc.identifier.urihttps://doi.org/10.26650/experimed.1268503
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11628
dc.identifier.volume13
dc.identifier.wosWOS:001322146800002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorCansız, Derya
dc.language.isoen
dc.publisherIstanbul University Press
dc.relation.ispartofExperimed
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial 4.0 International
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/deed.en
dc.subjectGingipain
dc.subjectZebrafish
dc.subjectOxidative Stress
dc.titleGingipain injection affects intestinal oxidant-antioxidant status and alkaline phosphatase in overfed zebrafish
dc.typeArticle

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