Antiproliferative and apoptotic effects of onobrychis albiflora extract on HCT-116 cells

Basit Öğe Kaydı
dc.authorid0000-0002-8084-7855
dc.authorid0000-0002-7059-1884
dc.contributor.authorBülbül, Muhammet Volkan
dc.contributor.authorÖzbek, Hanefi
dc.contributor.authorBahadır Acıkara, Özlem
dc.contributor.authorÖzbilgin, Serkan
dc.contributor.authorErgene Öz, Burçin
dc.contributor.authorKurtul, Ekin
dc.contributor.authorKeskin, İlknur
dc.date.accessioned2022-03-02T06:04:17Z
dc.date.available2022-03-02T06:04:17Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractIn this study, the cytotoxic effects of the extracts of methanol: water (80:20) prepared from the above-ground parts of the varieties of Onobrychis albiflora Hub.-Mor., Onobrychis argyrea Boiss. subsp. argyrea, Onobrychis galegifolia Boiss. and Onobrychis tournefortii (Willd.) Desv. species to HCT-116 cells were investigated. With cytotoxicity analysis that with these species inhibitor concentrations (IC50) which resulted in a 50% reduction in the proliferation of HCT-116 cells were identified. In continuation of the study; the antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT-116 cells were evaluated by Caspase 3, Annexin V / PI Apoptosis / Necrosis analysis, Apopxin Green and 7-AAD Apoptosis / Necrosis analysis. The antiproliferative, apoptotic and necrotic effects of Onobrychis albiflora extract on HCT-116 cells also were determined.
dc.identifier.citationBülbül, M. V., Özbek, H., Bahadır Acıkara, Ö., Özbilgin, S., Ergene Öz, B., Kurtul, E. ... Keskin, İ. (2018). Antiproliferative and apoptotic effects of onobrychis albiflora extract on HCT-116 cells. Journal of Experimental and Clinical Medicine (Turkey), 35(4), 101-109. https://doi.org/10.5835/jecm.omu.35.04.003
dc.identifier.doi10.5835/jecm.omu.35.04.003
dc.identifier.endpage109
dc.identifier.issn1309-4483
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85105280785
dc.identifier.scopusqualityQ4
dc.identifier.startpage101
dc.identifier.urihttps://doi.org/10.5835/jecm.omu.35.04.003
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9051
dc.identifier.volume35
dc.indekslendigikaynakScopus
dc.institutionauthorBülbül, Muhammet Volkan
dc.institutionauthorÖzbek, Hanefi
dc.institutionauthorKeskin, İlknur
dc.language.isoen
dc.publisherOndokuz Mayıs University
dc.relation.ispartofJournal of Experimental and Clinical Medicine (Turkey)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectApoptosis
dc.subjectFlow Cytometry
dc.subjectHCT-116
dc.subjectHEK-293
dc.subjectNecrosis
dc.titleAntiproliferative and apoptotic effects of onobrychis albiflora extract on HCT-116 cells
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Bulbul-Muhammet-2018.pdf
Boyut:
697.61 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Makale Koleksiyonu
Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu