Evaluation of perilipin expression in centrifuged fat grafts on different revolutions per minute and duration combinations

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dc.contributor.authorEskalen, Alper
dc.contributor.authorIşık, Eray
dc.contributor.authorÖzdemir, İlkay
dc.contributor.authorKeskin, İlknur
dc.contributor.authorKeskin, Mustafa
dc.contributor.authorKaracaoğlan, Naci
dc.date.accessioned2025-12-08T11:22:50Z
dc.date.available2025-12-08T11:22:50Z
dc.date.issued2025
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Plastik, Rekonstrüktif ve Estetik Cerrahi Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractFat graft applications are one of the most frequently used procedures in reconstructive and aesthetic surgery. Fat graft survival rate is variable and depends on many parameters. Those are the features of recipient area, method of obtaining the fat graft, the procedures applied to the harvest to get pure fat graft and the application techniques. In this study, we aimed to find the optimal revolutions per minute(rpm) and duration to be used in the centrifugation technique, which is one of the most frequently used methods in fat grafting. In our study, we used perilipin protein as a survival marker. Liposuction samples were obtained from 10 Caucasian women individuals; whose age range is between 22 and 29 years without any other reported health problem. Fat grafts from all patients were taken by the same surgical team by the same liposuction procedure. The grafts obtained in our study were divided into 6 different groups, these are A1 group (1 minute–1000 rpm) A2 group (3 minutes–1000 rpm) A3 group (5 minutes–1000 rpm) B1 group (1 minute–3000 rpm) B2 group (3 minutes–3000 rpm) and B3 group (5 minutes–3000 rpm). Perilipin expression measurements were made in the sections taken by immunohistochemistry technique. Three minutes–3000 rpm combination (B2 group) was found to be perilipin stained statistically significantly higher than other combinations. This study seeks to make a notable contribution to the literature by demonstrating the relation between frequently used centrifuge combinations and measuring the expression of perilipin. This protein’s role in adipocyte regulation is becoming increasingly apparent. Level of Evidence III This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
dc.identifier.citationEskalen, A., Işık, E., Özdemir, İ., Keskin, İ., Keskin, M. ve Karacaoğlan, N. (2025). Evaluation of perilipin expression in centrifuged fat grafts on different revolutions per minute and duration combinations. Aesthetic Plastic Surgery, 49(5), 1387-1395. http://dx.doi.org/10.1007/s00266-024-04580-3
dc.identifier.doi10.1007/s00266-024-04580-3
dc.identifier.endpage1395
dc.identifier.issn0364-216X
dc.identifier.issn1432-5241
dc.identifier.issue5
dc.identifier.pmid39663219
dc.identifier.scopus2-s2.0-105001972479
dc.identifier.scopusqualityQ1
dc.identifier.startpage1387
dc.identifier.urihttp://dx.doi.org/10.1007/s00266-024-04580-3
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13302
dc.identifier.volume49
dc.identifier.wosWOS:001375473300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorIşık, Eray
dc.institutionauthorÖzdemir, İlkay
dc.institutionauthorKeskin, İlknur
dc.institutionauthorKaracaoğlan, Naci
dc.institutionauthorid0000-0003-1024-2663
dc.institutionauthorid0000-0003-2715-6825
dc.institutionauthorid0000-0002-7059-1884
dc.institutionauthorid0000-0001-5878-2939
dc.language.isoen
dc.relation.ispartofAesthetic Plastic Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectCentrifuge
dc.subjectFat Graft
dc.subjectLiposuction
dc.subjectPerilipin
dc.titleEvaluation of perilipin expression in centrifuged fat grafts on different revolutions per minute and duration combinations
dc.typeArticle

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