Development of acoustically active nanocones using the host-guest interaction as a new histotripsy agent

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dc.authorid0000-0002-8548-6104
dc.authorid0000-0002-4634-3864
dc.authorid0000-0003-2776-5807
dc.contributor.authorRehman, Tanzeel Ur
dc.contributor.authorKhirallah, Jennifer
dc.contributor.authorDemirel, Erhan
dc.contributor.authorHowell, Justin
dc.contributor.authorVlaisavljevich, Eli
dc.contributor.authorYüksel Durmaz, Yasemin
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:43Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:43Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümü
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.descriptionWOS: 000460237300188
dc.description.abstractHistotripsy is a noninvasive and nonthermal ultrasound ablation technique, which mechanically ablates the tissues using very short, focused, high-pressured ultrasound pulses to generate dense cavitating bubble cloud. Histotripsy requires large negative pressures (>= 28 MPa) to generate cavitation in the target tissue, guided by real-time ultrasound imaging guidance. The high cavitation threshold and reliance on real-time image guidance are potential limitations of histotripsy, particularly for the treatment of multifocal or metastatic cancers. To address these potential limitations, we have recently developed nanoparticle-mediated histotripsy (NMH) where perfluorocarbon (PFC)-filled nanodroplets (NDs) with the size of similar to 200 nm were used as cavitation nuclei for histotripsy, as they are able to significantly lower the cavitation threshold. However, although NDs were shown to be an effective histotripsy agent, they pose several issues. Their generation requires multistep synthesis, they lack long-term stability, and determination of PFC concentration in the treatment dose is not possible. In this study, PFC-filled nanocones (NCs) were developed as a new generation of histotripsy agents to address the mentioned limitations of NDs. The developed NCs represent an inclusion complex of methylated beta-cyclodextrin as a water-soluble analog of beta-cyclodextrin and perfluorohexane (PFH) as more effective PFC derivatives for histotripsy. Results showed that NCs are easy to produce, biocompatible, have a size <50 nm, and have a quantitative complexation that allows us to directly calculate the PFH amount in the used NC dose. Results further demonstrated that NCs embedded into tissue-mimicking phantoms generated histotripsy cavitation "bubble clouds" at a significantly lower transducer amplitude compared to control phantoms, demonstrating the ability of NCs to function as effective histotripsy agents for NMH.
dc.description.sponsorshipLOreal-UNESCO "For Women in Science" Programen_US
dc.description.sponsorshipThe author (Y.Y.D.) thanks LOreal-UNESCO "For Women in Science" Program for financial support of this work.en_US
dc.identifier.citationRehman, T. U., Khirallah, J., Demirel, E., Howell, J., Vlaisavljevich, E. ve Yüksel Durmaz, Y. (2019). Development of acoustically active nanocones using the host-guest ınteraction as a new histotripsy agent. ACS Omega, 4(2), 4176-4184. https://dx.doi.org/10.1021/acsomega.8b02922
dc.identifier.doi10.1021/acsomega.8b02922
dc.identifier.endpage4184
dc.identifier.issn2470-1343
dc.identifier.issue2
dc.identifier.scopusqualityQ1
dc.identifier.startpage4176
dc.identifier.urihttps://dx.doi.org/10.1021/acsomega.8b02922
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1729
dc.identifier.volume4
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.relation.ispartofACS Omegaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHistotripsy
dc.subjectNanocones
dc.subjectNCs
dc.titleDevelopment of acoustically active nanocones using the host-guest interaction as a new histotripsy agent
dc.typeArticle

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