Active shrinkage protects neurons following axonal transection
| dc.authorid | 0000-0002-6393-1465 | |
| dc.authorid | 0000-0001-8089-1330 | |
| dc.authorid | 0000-0001-9037-5217 | |
| dc.authorid | 0000-0001-9403-2844 | |
| dc.authorid | 0000-0002-4243-9092 | |
| dc.authorid | 0000-0002-3386-1734 | |
| dc.authorid | 0000-0002-9373-0808 | |
| dc.authorid | 0000-0003-0352-1947 | |
| dc.contributor.author | Aydın, Mehmet Şerif | |
| dc.contributor.author | Bay, Sadık | |
| dc.contributor.author | Yiğit, Esra Nur | |
| dc.contributor.author | Özgül, Cemil | |
| dc.contributor.author | Kaval Oğuz, Elif | |
| dc.contributor.author | Yenidünya Konuk, Elçin | |
| dc.contributor.author | Ayşit, Neşe | |
| dc.contributor.author | Cengiz, Nureddin | |
| dc.contributor.author | Erdoğan, Ender | |
| dc.contributor.author | Him, Aydın | |
| dc.contributor.author | Koçak, Mehmet | |
| dc.contributor.author | Eroğlu, Emrah | |
| dc.contributor.author | Öztürk, Gürkan | |
| dc.date.accessioned | 2023-09-15T07:20:32Z | |
| dc.date.available | 2023-09-15T07:20:32Z | |
| dc.date.issued | 2023 | |
| dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) | |
| dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü | |
| dc.department | İstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik ve Tıp Bilişimi Ana Bilim Dalı | |
| dc.department | İstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı | |
| dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı | |
| dc.description.abstract | Trauma, vascular events, or neurodegenerative processes can lead to axonal injury and eventual transection (axotomy). Neurons can survive axotomy, yet the underlying mechanisms are not fully understood. Excessive water entry into injured neurons poses a particular risk due to swelling and subsequent death. Using in vitro and in vivo neurotrauma model systems based on laser transection and surgical nerve cut, we demonstrated that axotomy triggers actomyosin contraction coupled with calpain activity. As a consequence, neurons shrink acutely to force water out through aquaporin channels preventing swelling and bursting. Inhibiting shrinkage increased the probability of neuronal cell death by about 3-fold. These studies reveal a previously unrecognized cytoprotective response mechanism to neurotrauma and offer a fresh perspective on pathophysiological processes in the nervous system. | |
| dc.description.sponsorship | Yüzüncü Yıl University | en_US |
| dc.identifier.citation | Aydın, M. Ş., Bay, S., Yiğit, E. N., Özgül, C., Kaval Oğuz, E., Yenidünya Konuk, E. ... Öztürk, G. (2023). Active shrinkage protects neurons following axonal transection. iScience, 26(10). https://dx.doi.org/10.1016/j.isci.2023.107715 | |
| dc.identifier.doi | 10.1016/j.isci.2023.107715 | |
| dc.identifier.issn | 2589-0042 | |
| dc.identifier.issue | 10 | |
| dc.identifier.pmid | 37701578 | |
| dc.identifier.scopus | 2-s2.0-85170241467 | |
| dc.identifier.scopusquality | Q1 | |
| dc.identifier.uri | https://dx.doi.org/10.1016/j.isci.2023.107715 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12511/11439 | |
| dc.identifier.volume | 26 | |
| dc.identifier.wos | 001073070600001 | en_US |
| dc.identifier.wosquality | Q1 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.institutionauthor | Aydın, Mehmet Şerif | |
| dc.institutionauthor | Bay, Sadık | |
| dc.institutionauthor | Yiğit, Esra Nur | |
| dc.institutionauthor | Özgül, Cemil | |
| dc.institutionauthor | Ayşit, Neşe | |
| dc.institutionauthor | Koçak, Mehmet | |
| dc.institutionauthor | Eroğlu, Emrah | |
| dc.institutionauthor | Öztürk, Gürkan | |
| dc.language.iso | en | |
| dc.publisher | Elsevier Inc. | |
| dc.relation.ispartof | iScience | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.relation.tubitak | info:eu-repo/grantAgreement/TUBITAK/SOBAG/107S358 | |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
| dc.subject | Biological Sciences | |
| dc.subject | Neuroscience | |
| dc.subject | Physiology | |
| dc.title | Active shrinkage protects neurons following axonal transection | |
| dc.type | Article |
