Evaluation of nitric oxide levels in chronic periodontitis patients treated with initial periodontal therapy and probiotic food supplements: a double blind, randomized controlled clinical trial

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dc.authorid0000-0003-0804-1475
dc.contributor.authorİnce Kuka, Gizem
dc.contributor.authorGürsoy, Hare
dc.contributor.authorEmekli Alturfan, Ebru
dc.contributor.authorÜstündağ, Ünsal Veli
dc.contributor.authorKuru, Bahar
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:49:45Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:49:45Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.descriptionWOS: 000472514300001
dc.description.abstractThe aim of the present study was to analyse the nitric oxide (NO) levels in gingival crevicular fluid (GCF) of patients with chronic periodontitis (CP) treated with probiotic-containing food supplements as an adjunct to initial periodontal therapy (IPT). The present study was a randomized, double blind clinical trial conducted in Yeditepe University Dental Hospital, Istanbul, Turkey. Thirty-six CP patients, with >= 2 nonmolar teeth in each quadrant with probing depth (PD) of 5-7 mm at proximal sites and radiologically detectable horizontal alveolar bone loss were randomized into two treatment groups. The test group received IPT + probiotic-containing food supplements, whereas the control group received IPT + placebo. GCF sampling was performed at the baseline and 3 and 6 months after treatment. The biochemical evaluation of NO in GCF was performed using the Griess colourimetric method. Statistical analysis was performed by using statistical software. Significant reductions in GCF volume and GCF NO levels were detected in each group after the treatments (p < 0.05). Intergroup comparison of the NO levels revealed statistically significant differences in favour of the test group at both 3 and 6-month evaluation periods (p < 0.05). Adjunctive usage of probiotic comprising food supplements to IPT yielded significant reduction of the NO levels compared to the control for up to 6 months of follow-up. The present study is registered at Thai Clinical Trials Registry (TCTR identification number: TCTR20171114003).
dc.identifier.citationİnce Kuka, G., Gürsoy, H., Emekli Alturfan, E., Üstündağ, Ü. V. ve Kuru, B. (2019). Evaluation of nitric oxide levels in chronic periodontitis patients treated with initial periodontal therapy and probiotic food supplements: a double blind, randomized controlled clinical trial. Biotechnology & Biotechnological Equipment, 33(1), 974-979. https://dx.doi.org/10.1080/13102818.2019.1632740
dc.identifier.doi10.1080/13102818.2019.1632740
dc.identifier.endpage979
dc.identifier.issn1310-2818
dc.identifier.issn1314-3530
dc.identifier.issue1
dc.identifier.scopusqualityQ3
dc.identifier.startpage974
dc.identifier.urihttps://dx.doi.org/10.1080/13102818.2019.1632740
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1751
dc.identifier.volume33
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofBiotechnology & Biotechnological Equipmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectNitric Oxide
dc.subjectGingival Crevicular Fluid
dc.subjectChronic Periodontitis
dc.subjectInitial Periodontal Therapy
dc.subjectProbiotic Food Supplements
dc.titleEvaluation of nitric oxide levels in chronic periodontitis patients treated with initial periodontal therapy and probiotic food supplements: a double blind, randomized controlled clinical trial
dc.typeArticle

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