Concordance of PD-L1 expression and CD8+ TIL intensity between NSCLC and synchronous brain metastases

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dc.authorid0000-0003-0128-6947
dc.contributor.authorBatur, Şebnem
dc.contributor.authorDülger, Onur
dc.contributor.authorDurak, Şermin
dc.contributor.authorYumuk, Perran Fulden
dc.contributor.authorÇağlar, Hale Başak
dc.contributor.authorBozkurtlar, Emine
dc.contributor.authorBozkurt, Süheyla
dc.contributor.authorTaştekin, Ebru
dc.contributor.authorÇiçin, İrfan
dc.contributor.authorAhiskalı, Rengin
dc.contributor.authorÇakır, Aslı
dc.contributor.authorÖz, Büge
dc.date.accessioned2020-03-23T06:16:12Z
dc.date.available2020-03-23T06:16:12Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyasyon Onkolojisi Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractProgrammed death-ligand 1 (PD-L1) is suggested to be a predictive biomarker in non-small-cell lung carcinoma (NSCLC). However, the differential expression of PD-L1 in primary lung tumor vs. synchronous metastases, especially brain metastasis (BM), remains unclear. This study assessed the concordance of PD-L1 expression on tumor cells and tumor-infiltrating lymphocytes (TILs) and CD8+ TIL intensity between primary lung tumors and synchronous BMs from 24 NSCLC patients. PD-L1, CD3, and CD8 positivity was determined by immunohistochemistry (IHC). PD-L1 scoring was based on the proportion of tumor cells with membranous expression of PD-L1 and the cutoff values <1%, 1–49%, and ?50%. CD3 and CD8 positivity in TILs was evaluated semi-quantitatively and the proportion of CD3+/CD8+ TILs was determined. PD-L1 expression on tumor cells and TILs was evaluated in relation to CD3+/CD8+ TIL proportions and the intensity of CD8+ TILs between the paired primary lung and BM tissues. In the primary lung tumors, PD-L1 positivity was observed in 25%, 37.5%, and 37.5% cases for the cutoff values <1%, 1–49%, and ?50%, respectively. PD-L1 expression on tumor cells was strongly correlated between the paired primary lung and BM tissues, in all cutoff groups. However, PD-L1 expression on TILs and the proportion of CD3+/CD8+ TILs were not strongly correlated in all three groups between the paired primary lung tumors and BMs. The intensity of CD8+ TILs was concordant in only 54.16% of the paired primary lung tumors and BMs. This study showed a high concordance of PD-L1 expression in neoplastic cells between primary NSCLC and synchronous BMs.
dc.identifier.citationBatur, Ş., Dülger, O., Durak, Ş., Yumuk, P. F., Çağlar, H. B., Bozkurtlar, E. ... Öz, B. (2020). Concordance of PD-L1 expression and CD8+ TIL intensity between NSCLC and synchronous brain metastases. Bosnian Journal of Basic Medical Sciences, 20(3), 329-335. https://doi.org/10.17305/bjbms.2019.4474
dc.identifier.doi10.17305/bjbms.2019.4474
dc.identifier.endpage335
dc.identifier.issue3
dc.identifier.scopusqualityQ2
dc.identifier.startpage329
dc.identifier.urihttps://doi.org/10.17305/bjbms.2019.4474
dc.identifier.urihttps://hdl.handle.net/20.500.12511/5056
dc.identifier.volume20
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofBosnian Journal of Basic Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectProgrammed Death-Ligand 1
dc.subjectNon-Small-Cell Lung Cancer
dc.subjectNSCLC
dc.subjectTumor Immunology
dc.subjectPD-L1
dc.subjectBrain Metastasis
dc.subjectCD8 Lymphocytes
dc.subjectTumor Infiltrating Lymphocytes
dc.subjectTILs
dc.titleConcordance of PD-L1 expression and CD8+ TIL intensity between NSCLC and synchronous brain metastases
dc.typeArticle

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