The effect of water-soluble alpinia galanga extract on sleep and the activation of the gabaaergic/serotonergic pathway in mice
| dc.contributor.author | Şahin, Kazım | |
| dc.contributor.author | Korkusuz, Ahmet Kayhan | |
| dc.contributor.author | Şahin, Emre | |
| dc.contributor.author | Orhan, Cemal | |
| dc.contributor.author | Er, Beşir | |
| dc.contributor.author | Morde, Abhijeet | |
| dc.contributor.author | Kılıç, Ertuğrul | |
| dc.date.accessioned | 2026-01-06T16:52:59Z | |
| dc.date.available | 2026-01-06T16:52:59Z | |
| dc.date.issued | 2024 | |
| dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı | |
| dc.description.abstract | Background/Objectives: With increasing interest in plant-based compounds that can enhance sleep quality without the side effects of caffeine, Alpinia galanga (AG) has emerged as a promising herbal supplement for improving mental alertness. This study assessed the impact of water-soluble AG extract on sleep quality; the activity of GABAergic, glutamatergic, and serotonergic receptors; and concentrations of dopamine and serotonin in the brains of mice. Methods: The study employed two experimental models using BALB/c mice to examine the impact of pentobarbital-induced sleep and caffeine-induced insomnia. In the first model, a set of 20 mice was assigned to four groups to assess the effects of pentobarbital (42 mg/kg) or pentobarbital with AG extract on sleep induction, with observations made 45 min post-administration. In the second model, 20 mice were divided into four groups to evaluate the impact of caffeine (25 mg/kg) alone or caffeine with varying doses of AG extract (61.25 or 205.50 mg/kg administered orally) on brain activity along with additional analyses on receptor proteins and neurotransmitters. Results: A higher dose of AG extract (205.50 mg/kg) significantly increased total deep sleep duration compared to the caffeine group (p < 0.0001). Furthermore, this dose extended sleep latency and suppressed GABAergic and glutamatergic receptor activity compared to the lower AG dose (p < 0.05). Additionally, the 205.50 mg/kg dose elevated serotonin and dopamine levels compared to caffeine (p < 0.0001), suggesting improved sleep quality alongside enhanced wakefulness. Conclusions: Our data indicate that a higher dose of AG extract improved sleep latency and duration by regulating GABAergic and glutamatergic receptors through the GABAergic/serotonergic pathway in mice. | |
| dc.description.sponsorship | OmniActive Health Technologies ; Turkish Academy of Sciences | |
| dc.identifier.citation | Şahin, K., Korkusuz, A. K., Şahin, E., Orhan, C., Er, B., Morde, A. ... Kılıç, E. (2024). The effect of water-soluble alpinia galanga extract on sleep and the activation of the gabaaergic/serotonergic pathway in mice. Pharmaceuticals, 17(12). http://dx.doi.org/10.3390/ph17121649 | |
| dc.identifier.doi | 10.3390/ph17121649 | |
| dc.identifier.issn | 1424-8247 | |
| dc.identifier.issue | 12 | |
| dc.identifier.pmid | 39770491 | |
| dc.identifier.scopus | 2-s2.0-85213252564 | |
| dc.identifier.scopusquality | Q1 | |
| dc.identifier.uri | http://dx.doi.org/10.3390/ph17121649 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12511/13353 | |
| dc.identifier.volume | 17 | |
| dc.identifier.wos | WOS:001385493500001 | |
| dc.identifier.wosquality | Q1 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.institutionauthor | Korkusuz, Ahmet Kayhan | |
| dc.institutionauthorid | 0000-0003-3886-2151 | |
| dc.language.iso | en | |
| dc.relation.ec | info:eu-repo/grantAgreement/EC/FP7/2023-1 | |
| dc.relation.ec | info:eu-repo/grantAgreement/EC/FP7/2023-2 | |
| dc.relation.ispartof | Pharmaceuticals | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights | Attribution 4.0 International | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Alpinia Galanga | |
| dc.subject | Caffeine | |
| dc.subject | Gabaergic | |
| dc.subject | Neurotransmitters | |
| dc.subject | Sleep Quality | |
| dc.title | The effect of water-soluble alpinia galanga extract on sleep and the activation of the gabaaergic/serotonergic pathway in mice | |
| dc.type | Article |
