Does cigarette smoke exposure lead to histopathological alterations in the olfactory epithelium? An electron microscopic study on a rat model

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dc.authorid0000-0002-6813-8351
dc.contributor.authorŞahin, Elvan
dc.contributor.authorOrtuğ, Gürsel
dc.contributor.authorOrtuğ, Alpen
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:04:19Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:04:19Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Anatomi Ana Bilim Dalı
dc.descriptionWOS: 000450285900005
dc.descriptionPubMed ID: 30071177
dc.description.abstractObjective: This study was conducted to examine the influence of smoke exposure of variable duration on the ultrastructure of and histopathologic and morphologic alterations in the olfactory epithelium.Methods: A total of 24 Wistar albino rats were randomly assigned to three groups and fed a standard rat chow and tap water. Experimental rats in groups I and II were exposed to cigarette smoke in a glass cabin over a period of 2months for 5 or 15min, respectively, four times daily; control rats (group III) were not exposed to cigarette smoke. After dissection, all tissue specimens were processed using routine procedures for TEM.Results: Groups I and II exhibited the presence of intraepithelial inflammatory cells and especially deep invaginations in the nuclear membrane of supporting cells. Extended intercellular spaces, cytoplasmic protrusions on the apical surface of supporting cells, atrophy of microvilli and olfactory neuron cilia as well as numerous electron-dense granular structures and lysosome-like structures were observed to an increasing degree from group I to group II. Particularly in group II, both supporting cells and olfactory neurons exhibited a cytoplasmic edema, mitochondrial degeneration, and numerous vacuolar structures, as well as apoptotic and minimal necrotic changes. In this group, hyperplasia of basal cells was also observed.Conclusion: Our electron microscopic findings show that cigarette smoke leads to toxic degenerative changes in the rat olfactory mucosa.
dc.identifier.citationŞahin, E., Ortuğ, G. ve Ortuğ, A. (2018). Does cigarette smoke exposure lead to histopathological alterations in the olfactory epithelium? An electron microscopic study on a rat model. Ultrastructural Pathology, 42(5), 440-447. https://dx.doi.org/10.1080/01913123.2018.1499685
dc.identifier.doi10.1080/01913123.2018.1499685
dc.identifier.endpage447
dc.identifier.issn0191-3123
dc.identifier.issn1521-0758
dc.identifier.issue5
dc.identifier.scopusqualityQ3
dc.identifier.startpage440
dc.identifier.urihttps://dx.doi.org/10.1080/01913123.2018.1499685
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4032
dc.identifier.volume42
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofUltrastructural Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectElectron Microscopy
dc.subjectOlfactory Mucosa
dc.subjectPassive Smoking
dc.titleDoes cigarette smoke exposure lead to histopathological alterations in the olfactory epithelium? An electron microscopic study on a rat model
dc.typeArticle

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