Altered expression of micro-RNA 199a and increased levels of cardiac SIRT1 protein are associated with the occurrence of atrial fibrillation after coronary artery bypass graft surgery

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dc.authorid0000-0002-1079-8832
dc.authorid0000-0002-6895-8560
dc.contributor.authorYamaç, Aylin Hatice
dc.contributor.authorKüçükbuzcu, Sıtkı
dc.contributor.authorOzansoy, Mehmet
dc.contributor.authorGök, Özlem
dc.contributor.authorÖz, Kürşat
dc.contributor.authorErtürk, Mehmet
dc.contributor.authorYılmaz, Emre
dc.contributor.authorErsoy, Burak
dc.contributor.authorZeybek, Rahmi
dc.contributor.authorGöktekin, Ömer
dc.contributor.authorKılıç, Ülkan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:51:00Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:51:00Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Patoloji Ana Bilim Dalı
dc.descriptionWOS: 000375860400011
dc.descriptionPubMed ID: 26952538
dc.description.abstractBackground: Postoperative atrial fibrillation (POAF) is a potentially life-threatening complication after coronary artery bypass graft (CABG) surgery. The expression of the cardioprotective SIRT1 protein with its antioxidant activity is increased in cardiac tissue of patients suffering from POAF. So far, information is lacking about the relationship between SIRT1 regulating micro RNAs (miRs), SIRT1 protein and the occurrence of POAF. Methods: A total of 63 patients undergoing CABG were recruited, and biopsies were obtained from the right atrial appendage during cannulation. Postoperative, all patients were rhythm-monitored until discharge and randomized to POAF (n= 20) or sinus rhythm (n= 43). The expression of the micro RNAs miR-199a and miR-195 was quantified by real-time PCR. SIRT1 protein was detected by western blot analysis. Results: The relative expression of miR-199a in the POAF group was significantly decreased compared to the control group (0.77 +/- 0.27 vs. 1.11 +/- 0.69, P=. 022) Accordingly, SIRT 1 protein was significantly induced in tissue probes of patients with POAF (P<. 001). Conclusion: Altered expression of the SIRT1 protein regulating miR-199a in human atrial tissue was found to be related to the occurrence of POAF, indicating its usefulness as a biomarker for cardiac surgery management.
dc.description.sponsorshipScience Foundation BAP of the Bezmialem Vakif University (BAP) [3.2015/28]en_US
dc.description.sponsorshipThis research received funding from the Science Foundation BAP of the Bezmialem Vakif University (BAP number 3.2015/28).en_US
dc.identifier.citationYamaç, A. H., Küçükbuzcu, S., Ozansoy, M., Gök, Ö., Öz, K., Ertürk, M. ... Kılıç, Ü. (2016). Altered expression of micro-RNA 199a and increased levels of cardiac SIRT1 protein are associated with the occurrence of atrial fibrillation after coronary artery bypass graft surgery. Cardiovascular Pathology, 25(3), 232-236. https://dx.doi.org/10.1016/j.carpath.2016.02.002
dc.identifier.doi10.1016/j.carpath.2016.02.002
dc.identifier.endpage236
dc.identifier.issn1054-8807
dc.identifier.issn1879-1336
dc.identifier.issue3
dc.identifier.scopusqualityQ1
dc.identifier.startpage232
dc.identifier.urihttps://dx.doi.org/10.1016/j.carpath.2016.02.002
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2125
dc.identifier.volume25
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofCardiovascular Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectPostoperative Atrial Fibrillation
dc.subjectMiR-199a
dc.subjectSIRT 1 protein
dc.titleAltered expression of micro-RNA 199a and increased levels of cardiac SIRT1 protein are associated with the occurrence of atrial fibrillation after coronary artery bypass graft surgery
dc.typeArticle

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