Magnetic resonance-based pelvimetry and tumor volumetry can predict surgical difficulty and oncologic outcome in locally advanced mid-low rectal cancer

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dc.authorid0000-0002-2282-7207
dc.contributor.authorAtasoy, Gülşen
dc.contributor.authorArslan, Naciye Çiğdem
dc.contributor.authorDinç Elibol, Funda
dc.contributor.authorSa?ol, Özgül
dc.contributor.authorObuz, Funda
dc.contributor.authorSökmen, Selman
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:00Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:00Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.descriptionWOS: 000447980700002
dc.descriptionPubMed ID: 29961173
dc.description.abstractPurposeTo investigate the impact of the pelvic dimensions and tumor volume on surgery in locally advanced rectal cancer.MethodsPatients who underwent open surgery after neoadjuvant long-course chemoradiation for primary rectal cancer were included. The predictive value of magnetic resonance-based pelvic measurements and tumor volume on the surgical difficulty and oncologic outcome were analyzed.Results125 patients were included. The independent risk factors related to the circumferential resection margin status were the pT stage [odds ratio (OR) 3.64, confidence interval (CI) 1.409-7.327] and tumor volume after neoadjuvant chemoradiotherapy (OR 1.59, CI 1.018-2.767). The operative time (p=0.014, OR 1.453) and pelvic depth (p=0.023, OR 1.116) were independent predictive factors for anastomotic leak. The median follow-up was 72 (2-113) months. Local recurrence was seen in 17 (14.1%) patients. Anastomotic leak (OR 1.799, CI 0.978-3.277), the circumferential resection margin status (OR 3.217, CI 1.262-7.870) and the relative tumor volume rate (OR 1.260, CI 1.004-1.912) were independent prognosticators of local recurrence. The 5-year overall survival was 66.7%. The circumferential resection margin status (hazard ratio: 4.739, CI 2.276-9.317), pN stage (OR 3.267, CI 1.195-8.930) and relative tumor volume rate (OR 2.628, CI 1.042-6.631) were independent prognostic factors for the overall survival.ConclusionsRelative dimensions of the tumor in the pelvis influence the local recurrence and overall survival rates. Magnetic resonance-based measurements can predict the difficulty of surgery and allow surgeons to consider the appropriate surgical approach.
dc.identifier.citationAtasoy, G., Arslan, N. Ç., Dinç Elibol, F., Sa?ol, Ö., Obuz, F. ve Sökmen, S. (2018). Magnetic resonance-based pelvimetry and tumor volumetry can predict surgical difficulty and oncologic outcome in locally advanced mid-low rectal cancer. Surgery Today, 48(12), 1040-1051. https://dx.doi.org/10.1007/s00595-018-1690-3
dc.identifier.doi10.1007/s00595-018-1690-3
dc.identifier.endpage1051
dc.identifier.issn0941-1291
dc.identifier.issn1436-2813
dc.identifier.issue12
dc.identifier.scopusqualityQ2
dc.identifier.startpage1040
dc.identifier.urihttps://dx.doi.org/10.1007/s00595-018-1690-3
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1844
dc.identifier.volume48
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Tokyo
dc.relation.ispartofSurgery Todayen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPelvimetry
dc.subjectMagnetic Resonance
dc.subjectRectal Cancer
dc.subjectSurvival
dc.subjectLocal Recurrence
dc.titleMagnetic resonance-based pelvimetry and tumor volumetry can predict surgical difficulty and oncologic outcome in locally advanced mid-low rectal cancer
dc.typeArticle

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