Resting state alpha electroencephalographic rhythms are differently related to aging in cognitively unimpaired seniors and patients with alzheimer's disease and amnesic mild cognitive impairment

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dc.authorid0000-0002-0860-0524
dc.authorid0000-0002-7555-3801
dc.authorid0000-0003-4292-5717
dc.contributor.authorBabiloni, Claudio
dc.contributor.authorFerri, Raffaele
dc.contributor.authorNoce, Giuseppe
dc.contributor.authorLizio, Roberta
dc.contributor.authorLopez, Susanna
dc.contributor.authorLorenzo, Ivan
dc.contributor.authorTucci, Federico
dc.contributor.authorSoricelli, Andrea
dc.contributor.authorNobili, Flavio
dc.contributor.authorArnaldi, Dario
dc.contributor.authorFama, Francesco
dc.contributor.authorOrzi, Francesco
dc.contributor.authorButtinelli, Carla
dc.contributor.authorGiubilei, Franco
dc.contributor.authorCipollini, Virginia
dc.contributor.authorMarizzoni, Moira
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorAktürk, Tuba
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorYener, Görsev
dc.contributor.authorÖzbek, Yağmur
dc.contributor.authorStocchi, Fabrizio
dc.contributor.authorVacca, Laura
dc.contributor.authorFrisoni, Giovanni B.
dc.contributor.authordel Percio, Claudio
dc.date.accessioned2021-08-19T08:28:56Z
dc.date.available2021-08-19T08:28:56Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı
dc.description.abstractBackground: In relaxed adults, staying in quiet wakefulness at eyes closed is related to the so-called resting state electroencephalographic (rsEEG) rhythms, showing the highest amplitude in posterior areas at alpha frequencies (8-13 Hz). Objective: Here we tested the hypothesis that age may affect rsEEG alpha (8-12 Hz) rhythms recorded in normal elderly (Nold) seniors and patients with mild cognitive impairment due to Alzheimer's disease (ADMCI). Methods: Clinical and rsEEG datasets in 63 ADMCI and 60 Nold individuals (matched for demography, education, and gender) were taken from an international archive. The rsEEG rhythms were investigated at individual delta, theta, and alpha frequency bands, as well as fixed beta (14-30 Hz) and gamma (30-40 Hz) bands. Each group was stratified into three subgroups based on age ranges (i.e., tertiles). Results: As compared to the younger Nold subgroups, the older one showed greater reductions in the rsEEG alpha rhythms with major topographical effects in posterior regions. On the contrary, in relation to the younger ADMCI subgroups, the older one displayed a lesser reduction in those rhythms. Notably, the ADMCI subgroups pointed to similar cerebrospinal fluid AD diagnostic biomarkers, gray and white matter brain lesions revealed by neuroimaging, and clinical and neuropsychological scores. Conclusion: The present results suggest that age may represent a deranging factor for dominant rsEEG alpha rhythms in Nold seniors, while rsEEG alpha rhythms in ADMCI patients may be more affected by the disease variants related to earlier versus later onset of the AD.
dc.description.sponsorshipMinistry of Health, Italy ; IRCCS OASI Maria SS of Troina ; IRCCS San Raffaele Pisana of Romeen_US
dc.identifier.citationBabiloni, C., Ferri, R., Noce, G., Lizio, R., Lopez, S., Lorenzo, I. ... del Percio, C. (2021). Resting state alpha electroencephalographic rhythms are differently related to aging in cognitively unimpaired seniors and patients with alzheimer's disease and amnesic mild cognitive impairment. Journal of Alzheimer's Disease, 82(3), 1085-1114. https://dx.doi.org/10.3233/JAD-201271
dc.identifier.doi10.3233/JAD-201271
dc.identifier.endpage1114
dc.identifier.issn1387-2877
dc.identifier.issn1875-8908
dc.identifier.issue3
dc.identifier.scopusqualityQ1
dc.identifier.startpage1085
dc.identifier.urihttps://dx.doi.org/10.3233/JAD-201271
dc.identifier.urihttps://hdl.handle.net/20.500.12511/7873
dc.identifier.volume82
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherIOS Press
dc.relation.ispartofJournal of Alzheimer's Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAging
dc.subjectExact Low-Resolution Brain Electromagnetic Source Tomography
dc.subjectMild Cognitive Impairment due to Alzheimer's Disease
dc.subjectResting State Electroencephalographic Rhythms
dc.titleResting state alpha electroencephalographic rhythms are differently related to aging in cognitively unimpaired seniors and patients with alzheimer's disease and amnesic mild cognitive impairment
dc.typeArticle

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