Factors influencing mortality in covid-19-associated mucormycosis - the international ID-IRI study

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dc.authorid0000-0003-4147-3587
dc.authorid0000-0001-8022-7325
dc.authorid0000-0001-8945-2385
dc.authorid0000-0001-8213-6064
dc.authorid0000-0001-9658-7560
dc.contributor.authorŞahin, Meyha
dc.contributor.authorYılmaz, Mesut
dc.contributor.authorMert, Ali
dc.contributor.authorNaghili, Behrouz
dc.contributor.authorRavanbakhsh, Fatemeh
dc.contributor.authorVarshochi, Mojtaba
dc.contributor.authorAlavi Darazam, Ilad
dc.contributor.authorEbrahimi, Mohammad Javad
dc.contributor.authorMoafi, Maral
dc.contributor.authorTehrani, Hamed Azhdari
dc.contributor.authorMahboob, Amjad
dc.contributor.authorRashid, Naveed
dc.contributor.authorKhan, Ejaz Ahmed
dc.contributor.authorHakamifard, Atousa
dc.contributor.authorEser Karlıdağ, Gülden
dc.contributor.authorBabamahmoodi, Abdolreza
dc.contributor.authorEl-Kholy, Amani
dc.contributor.authorMosawi, Sayed Hussain
dc.contributor.authorAlbayrak, Ayşe
dc.contributor.authorWadi Al Ramahi, Jamal
dc.contributor.authorAddepalli, Syam Kumar
dc.contributor.authorBalin, Şafak Özer
dc.contributor.authorKhan, Asfandiyar
dc.contributor.authorPandya, Nirav
dc.contributor.authorGürbüz, Esra
dc.contributor.authorSincan, Gülden
dc.contributor.authorAzami, Hadia
dc.contributor.authorDumlu, Rıdvan
dc.contributor.authorKhedr, Reham
dc.contributor.authorRipon, Rezaul Karim
dc.contributor.authorAlkan, Sevil
dc.contributor.authorKöse, Şükran
dc.contributor.authorCeylan, Bahadır
dc.contributor.authorErdem, Hakan
dc.date.accessioned2024-07-03T07:42:12Z
dc.date.available2024-07-03T07:42:12Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractThe emergence of COVID-19, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), triggered a global pandemic. Concurrently, reports of mucormycosis cases surged, particularly during the second wave in India. This study aims to investigate mortality factors in COVID-19-associated mucormycosis (CAM) cases, exploring clinical, demographic, and therapeutic variables across mostly Asian and partly African countries. A retrospective, cross-sectional analysis of CAM patients from 22 medical centers across eight countries was conducted, focusing on the first three months post-COVID-19 diagnosis. Data collected through the IDI-IR included demographics, comorbidities, treatments, and outcomes. A total of 162 CAM patients were included. The mean age was 54.29±13.04 years, with 54% male. Diabetes mellitus (85%) was prevalent, and 91% had rhino-orbital-cerebral mucormycosis (ROCM). Surgical debridement was performed in 84% of the cases. Mortality was 39%, with advanced age [Hazard Ratio (HR)=1.06, (p<0.001)], rituximab use (HR=21.2, p=0.05), diabetic ketoacidosis (HR=3.58, p=0.009) identified as risk factors. The mortality risk increases by approximately 5.6% for each additional year of age. Surgical debridement based on organ involvement correlated with higher survival (HR=8.81, p<0.001). The utilization of rituximab and diabetic ketoacidosis along with advancing age, has been associated with an increased risk of mortality in CAM patients. A combination of antifungal treatment and surgical intervention has demonstrated a substantial improvement in survival outcomes.
dc.identifier.citationŞahin, M., Yılmaz, M., Mert, A., Naghili, B., Ravanbakhsh, F., Varshochi, M. ... Erdem, H. (2024). Factors influencing mortality in covid-19-associated mucormycosis - the international ID-IRI study. Medical Mycology, 62(7). http://dx.doi.org/10.1093/mmy/myae064
dc.identifier.doi10.1093/mmy/myae064
dc.identifier.issn1369-3786
dc.identifier.issn1460-2709
dc.identifier.issue7
dc.identifier.pmid38914466
dc.identifier.scopus2-s2.0-85199223686
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://dx.doi.org/10.1093/mmy/myae064
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12692
dc.identifier.volume62
dc.identifier.wos001272180500001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorŞahin, Meyha
dc.institutionauthorYılmaz, Mesut
dc.institutionauthorMert, Ali
dc.institutionauthorDumlu, Rıdvan
dc.institutionauthorCeylan, Bahadır
dc.language.isoen
dc.relation.ispartofMedical Mycologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCOVID-19
dc.subjectCOVID-19-Associated Mucormycosis
dc.subjectImmunosuppression
dc.subjectMortality
dc.titleFactors influencing mortality in covid-19-associated mucormycosis - the international ID-IRI study
dc.typeArticle

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