Effect of human papillomavirus subtype on the rate of positive surgical margin after cervical conization

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dc.contributor.authorPurut, Yunus Emre
dc.contributor.authorGiray, Burak
dc.contributor.authorAkış, Serkan
dc.contributor.authorKeleş Peker, Esra
dc.contributor.authorBabayeva, Gülçin
dc.contributor.authorKabaca, Canan
dc.contributor.authorApi, Murat
dc.date.accessioned2023-09-21T08:49:59Z
dc.date.available2023-09-21T08:49:59Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.description.abstractObjective. Human papillomavirus (HPV) infection is a risk factor for cervical carcinoma. Over 100 types of HPV have been identified. The excisional procedures are recommended for women with high-grade cervical intraepithelial neoplasia. Surgical margin status is an important predictor of the risk of relapse. The aim of the current study was to evaluate whether HPV genotype is a predictive factor of positive surgical margin after cervical cone excision. Materials and Methods. The records of 448 HPV-infected patients who underwent loop electrosurgical excision or cold knife conization at a tertiary gynecological cancer center were retrospectively reviewed. The patients were divided into 6 groups according to HPV positivity: HPV 16 only, HPV 18 only, HPV 16/18, other high-risk HPV (hrHPV), HPV 16/hrHPV, and HPV 18/hrHPV. Results. There was no significant difference between the HPV groups in terms of age, parity, menopausal status, endocervical canal involvement, conization method, and the rates of positive margin (P = .15, P = .49, P = .07, P = .20, P = .24, P = .39, respectively). Conclusion. The results show that HPV subtypes might not be associated with endocervical canal involvement and the rates of positive margin. In addition, margin status was not related to the conization method and the number of excised cervical tissue.
dc.identifier.citationPurut, Y. E., Giray, B., Akış, S., Keleş Peker, E., Babayeva, G., Kabaca, C. ... Api, M. (2023). Effect of human papillomavirus subtype on the rate of positive surgical margin after cervical conization. International Journal of Surgical Pathology, 31(1), 20-25. https://doi.org/10.1177/10668969221143460
dc.identifier.doi10.1177/10668969221143460
dc.identifier.endpage25
dc.identifier.issn1066-8969
dc.identifier.issn1940-2465
dc.identifier.issue1
dc.identifier.pmid36514291
dc.identifier.scopus2-s2.0-85144181499
dc.identifier.scopusqualityQ2
dc.identifier.startpage20
dc.identifier.urihttps://doi.org/10.1177/10668969221143460
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11479
dc.identifier.volume31
dc.identifier.wos000898297500001en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKabaca, Canan
dc.language.isoen
dc.publisherSAGE Publications Inc.
dc.relation.ispartofInternational Journal of Surgical Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCervical Intraepithelial Neoplasia
dc.subjectConization
dc.subjectHuman Papillomavirus
dc.subjectLoop Electrosurgical Excision
dc.titleEffect of human papillomavirus subtype on the rate of positive surgical margin after cervical conization
dc.typeArticle

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