Inappropriate use of digoxin in patients presenting with digoxin toxicity

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dc.contributor.authorTatlısu, Mustafa Adem
dc.contributor.authorÖzcan, Kazım Serhan
dc.contributor.authorGüngör, Barış
dc.contributor.authorZengin, Ahmet
dc.contributor.authorKarataş, Mehmet Baran
dc.contributor.authorNurkalem, Zekeriya
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:58:12Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:58:12Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.descriptionWOS: 000351866700008
dc.descriptionPubMed ID: 25870617
dc.description.abstractBackground Digoxin remains widely used today despite its narrow therapeutic index and toxicity. The objective of this study was to investigate the percentage of inappropriate use of digoxin and long-term outcomes of elderly patients hospitalized for digoxin toxicity. Methods The study included 99 consecutive patients hospitalized for digoxin toxicity. The other study criteria for the inappropriate use of digoxin was regarded if participants having depressed left ventricular systolic function (ejection fraction < 45%) who were not on optimal medical therapy including beta-blocker and angiotensin-converting-enzyme inhibitor therapy or if participants having permanent AF who were not on optimal beta-blocker therapy. Results Appropriate digoxin usage was confirmed in 33 of patients in spite of its narrow therapeutic index. A total of 16 of 99 patients died, with a mean follow-up time of 22.1 +/- 10.3 months. Conclusions Contrary to popular belief, the rate of inappropriate digoxin usage remains high. On account of its narrow therapeutic index and toxicity, digoxin should be used more carefully according to the current evidence and guidelines.
dc.identifier.citationTatlısu, M. A., Özcan, K. S., Güngör, B., Zengin, A., Karataş, M. B. ve Nurkalem, Z. (2015). Inappropriate use of digoxin in patients presenting with digoxin toxicity. Journal of Geriatric Cardiology, 12(2), 143-146. https://doi.org/10.11909/j.issn.1671 5411.2015.02.007
dc.identifier.doi10.11909/j.issn.1671-5411.2015.02.007
dc.identifier.endpage146
dc.identifier.issn1671-5411
dc.identifier.issue2
dc.identifier.scopusqualityQ2
dc.identifier.startpage143
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3126
dc.identifier.urihttps://doi.org/10.11909/j.issn.1671 5411.2015.02.007
dc.identifier.volume12
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherScience Press
dc.relation.ispartofJournal of Geriatric Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectDigoxin
dc.subjectEjection Fraction
dc.subjectIndications
dc.subjectToxicity
dc.titleInappropriate use of digoxin in patients presenting with digoxin toxicity
dc.typeArticle

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