Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and lymphocyte-monocyte ratio (LMR) in predicting systemic inflammatory response syndrome (SIRS) and sepsis after percutaneous nephrolithotomy (PNL)

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dc.authorid0000-0002-6308-1763
dc.authorid0000-0003-0906-4417
dc.contributor.authorKriplani, Akshay
dc.contributor.authorPandit, Shruti
dc.contributor.authorChawla, Arun
dc.contributor.authorde la Rosette, Jean J. M. C. H.
dc.contributor.authordel Pilar Laguna Pes, Maria
dc.contributor.authorReddy, Suraj Jayadeva
dc.contributor.authorSomani, Bhaskar K.
dc.date.accessioned2023-01-04T11:17:19Z
dc.date.available2023-01-04T11:17:19Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstractThe objective of this prospective observational study was to assess the clinical significance of neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and lymphocyte-monocyte ratio (LMR) as potential biomarkers to identify post-PNL SIRS or sepsis. Demographic data and laboratory data including hemoglobin (Hb), total leucocyte count (TLC), serum creatinine, urine microscopy and culture were collected. The NLR, LMR and PLR were calculated by the mathematical division of their absolute values derived from routine complete blood counts from peripheral blood samples. Stone factors were assessed by non-contrast computerized tomography of kidneys, ureter and bladder (NCCT KUB) and included stone burden (Volume = L x W x D x pi x 0.167), location and Hounsfield value and laterality. Intraoperative factors assessed were puncture site, tract size, tract number, operative time, the need for blood transfusion and stone clearance. Of 517 patients evaluated, 56 (10.8%) developed SIRS and 8 (1.5%) developed sepsis. Patients developing SIRS had significantly higher TLC (10.4 +/- 3.5 vs 8.6 +/- 2.6, OR 1.19, 95% CI 1.09-1.3, p = 0.000002), higher NLR (3.6 +/- 2.4 vs 2.5 +/- 1.04, OR 1.3, 95% CI = 1.09-1.5, p = 0.0000001), higher PLR (129.3 +/- 53.8 vs 115.4 +/- 68.9, OR 1.005, 95% CI 1.001-1.008, p = 0.005) and lower LMR (2.5 +/- 1.7 vs 3.2 +/- 1.8, OR 1.18, 95% CI 1.04-1.34, p = 0.006). Staghorn stones (12.8 vs 3.24%, OR 4.361, 95% CI 1.605-11.846, p = 0.008) and long operative times (59.6 +/- 14.01 vs 55.2 +/- 16.02, OR 1.01, 95% CI 1.00-1.03, p = 0.05) had significant association with postoperative SIRS. In conclusion, NLR, PLR and LMR can be useful independent, easily accessible and cost-effective predictors for early identification of post-PNL SIRS/sepsis.
dc.description.sponsorshipManipal Academy of Higher Education, Manipalen_US
dc.identifier.citationKriplani, A., Pandit, S., Chawla, A., de la Rosette, J. J. M. C. H., del Pilar Laguna Pes, M., Reddy, S. J. ... Somani, B. K. (2022). Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and lymphocyte-monocyte ratio (LMR) in predicting systemic inflammatory response syndrome (SIRS) and sepsis after percutaneous nephrolithotomy (PNL). Urolithiasis, 50(3), 341-348. https://dx.doi.org/10.1007/s00240-022-01319-0
dc.identifier.doi10.1007/s00240-022-01319-0
dc.identifier.endpage348
dc.identifier.issn2194-7228
dc.identifier.issn2194-7236
dc.identifier.issue3
dc.identifier.pmid35246692
dc.identifier.scopus2-s2.0-85125595369
dc.identifier.scopusqualityQ1
dc.identifier.startpage341
dc.identifier.urihttps://dx.doi.org/10.1007/s00240-022-01319-0
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10239
dc.identifier.volume50
dc.identifier.wos000764567600001en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorde la Rosette, Jean J. M. C. H.
dc.institutionauthordel Pilar Laguna Pes, Maria
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofUrolithiasisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectSIRS
dc.subjectPCNL
dc.subjectSepsis
dc.subjectRenal Stones
dc.subjectEndourology
dc.titleNeutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and lymphocyte-monocyte ratio (LMR) in predicting systemic inflammatory response syndrome (SIRS) and sepsis after percutaneous nephrolithotomy (PNL)
dc.typeArticle

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