The clinicopathologic characteristics and prognostic factors of gastroesophageal junction tumors according to Siewert classification

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dc.contributor.authorÖven Ustaalioğlu, Bala Başak
dc.contributor.authorTilki, Metin
dc.contributor.authorSümelioğlu, Ali
dc.contributor.authorBilici, Ahmet
dc.contributor.authorGönen, Can
dc.contributor.authorUstaalioğlu, Recep
dc.contributor.authorBalvan, Özlem
dc.contributor.authorAliustaoğlu, Mehmet
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:04:05Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:04:05Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000396634600006
dc.descriptionPubMed ID: 28589183
dc.description.abstractObjective: The treatment of gastroesophageal junction tumors remains controversial due to confusion on whether they should be considered as primary esophageal or as gastric tumors. The incidence of these tumors with poor prognosis has increased, thus creating scientific interest on gastroesophageal cancers. Esophagogastric cancers are classified according to their location by Siewert, and the treatment of each type varies. We evaluated the prognostic factors and differences in clinicopathologic factors of patients with gastroesophageal junction tumor, who have been treated and followed-up in our clinics. Material and Methods: We retrospectively analyzed 187 patients with gastroesophageal junction tumors who have been operated and treated in the Oncology Department between 2005 and 2014. The chi-square test was used to evaluate differences in clinicopathologic factors among Siewert groups I, II and III. Prognostic factors were analyzed by univariate and multivariate analysis. Results: The median age of our patients was 62 years, and approximately 70% was male. Nineteen patients (10.2%) had Siewert I tumors, 40 (21.4%) II, and the remaining 128 (64.4%) had Siewert III tumors. Siewert III tumors were at more advanced pathologic and T stages. Preoperative chemoradiotherapy was mostly applied to Siewert group I patients. There was no difference between the 3 groups in terms of recurrence. While the median overall survival and 2-year overall survival rate were 26.6 months and 39.6%, the median disease free survival and disease free survival rates were 16.5 months and 30.1%, respectively. The N stage, pathologic stage, vascular invasion, lymphatic invasion, perineural invasion, surgical margin, and grade were associated with both overall survival and disease free survival, while pathologic stage and presence of recurrence were significant factors for overall survival. The median disease free survival for Siewert III tumors was 20 months, 11.3 month for Siewert I tumors, and 14 months for Siewert II tumors, but the finding was not statistically significant (p= 0.08). Conclusion: Although gastroesophageal junction tumors were grouped according to their location and they exerted different clinicopathologic properties, their prognosis was similar.
dc.identifier.citationÖven Ustaalioğlu, B. B., Tilki, M., Sümelioğlu, A., Bilici, A., Gönen, C., Ustaalioğlu, R. ... Aliustaoğlu, M. (2017). The clinicopathologic characteristics and prognostic factors of gastroesophageal junction tumors according to Siewert classification. Turkish Journal of Sourgery, 33(1), 19-25. https://dx.doi.org/10.5152/UCD.2017.3379
dc.identifier.doi10.5152/UCD.2017.3379
dc.identifier.endpage25
dc.identifier.issn1300-0705
dc.identifier.issn1308-8521
dc.identifier.issue1
dc.identifier.scopusqualityQ3
dc.identifier.startpage19
dc.identifier.urihttps://dx.doi.org/10.5152/UCD.2017.3379
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3993
dc.identifier.volume33
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAVES
dc.relation.ispartofTurkish Journal of Sourgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEsophagogastric Junction
dc.subjectSiewert Classification
dc.subjectPrognosis
dc.titleThe clinicopathologic characteristics and prognostic factors of gastroesophageal junction tumors according to Siewert classification
dc.typeArticle

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