The importance of inflammatory biomarkers, IL-6 and PAPP-A, in the evaluation of asymptomatic apical periodontitis

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dc.authorid0000-0002-0354-5108
dc.contributor.authorŞirin, Dursun Ali
dc.contributor.authorÖzçelik, Fatih
dc.contributor.authorErşahan, Şeyda
dc.contributor.authorPençe, Halime Hanım
dc.date.accessioned2021-01-27T10:35:20Z
dc.date.available2021-01-27T10:35:20Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Endodonti Ana Bilim Dalı
dc.description.abstractTo examine the use of IL-6 and PAPP-A along with the new imaging for scoring methods to determine the severity of apical periodontitis (AP). The scoring of disease severity in 121 patients with AP, using dental radiographs, was based on "The Apical Periodontitis Grading Scale" (APGS), as those having 1 tooth with AP and severity of 3-4 were classified as grade 1 (mild); those having > 1 tooth and severity of 3-4 as grade 2 (moderate) and those with at least one tooth with a severity of 5 as grade 3 (severe). 45 systematically and orally healthy volunteers were selected as the control group (grade 0). Dental demographic data of all participants were recorded. Besides, venous blood samples were collected to study their complete blood count and levels of IL-6 and PAPP-A. Both NLR and PAPP-A levels of the grade 3 AP patients were found significantly higher than those of the control group and grade 1 and grade 2 AP patients (2.55 +/- 1.40 vs 1.98 +/- 1.05, 1.94 +/- 0.58 and 1.86 +/- 0.50; 0.606 +/- 0.211 vs 0.422 +/- 0.273, 0.447 +/- 0.224 and 0.436 +/- 0.242,p < 0.01, respectively). AP grades identified by the new scoring system were moderately correlated with IL-6 levels (Spearmanr = 0.4168,p < 0.001). The risk of patients with IL-6 levels above 12.5 pg/ml to develop AP (relative risk) was found to be 2.19 times higher than that in those with lower IL-6 levels (98% Cl 1.233-3.905,p < 0.0024). APGS classification suggested to determine AP severity was found to be significantly correlated with levels of inflammatory markers IL-6 and PAPP-A.
dc.identifier.citationŞirin, D. A., Özçelik, F., Erşahan, Ş. ve Pençe, H. H. (2021). The importance of inflammatory biomarkers, IL-6 and PAPP-A, in the evaluation of asymptomatic apical periodontitis. Odontology, 109(1), 250-258. https://dx.doi.org/10.1007/s10266-020-00534-8
dc.identifier.doi10.1007/s10266-020-00534-8
dc.identifier.endpage258
dc.identifier.issn1618-1247
dc.identifier.issn1618-1255
dc.identifier.issue1
dc.identifier.scopusqualityQ2
dc.identifier.startpage250
dc.identifier.urihttps://dx.doi.org/10.1007/s10266-020-00534-8
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6414
dc.identifier.volume109
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofOdontologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectApical Periodontitis
dc.subjectIL-6
dc.subjectPAPP-A
dc.titleThe importance of inflammatory biomarkers, IL-6 and PAPP-A, in the evaluation of asymptomatic apical periodontitis
dc.typeArticle

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