Risk factors for skeletal-related events (SREs) and factors affecting SRE-free survival for nonsmall cell lung cancer patients with bone metastases

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dc.contributor.authorUlaş, Arife
dc.contributor.authorBilici, Ahmet
dc.contributor.authorDurnalı, Ayşe
dc.contributor.authorTokluoğlu, Saadet
dc.contributor.authorAkıncı, Sema
dc.contributor.authorSilay, Kamile
dc.contributor.authorÖksüzoğlu, Berna
dc.contributor.authorAlkış, Necati
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:03:23Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:03:23Z
dc.date.issued2016
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyasyon Onkolojisi Ana Bilim Dalı
dc.descriptionWOS: 000374576200123
dc.descriptionPubMed ID: 26276360
dc.description.abstractSkeletal-related events (SREs) for nonsmall cell lung cancer (NSCLC) patients with bone metastasis lead to serious morbidity. The aim of this study was to determine risk factors for SREs in NSCLC patients with bone metastasis and the factors influencing SRE-free survival and overall survival (OS). From 2000 to 2012, we evaluated retrospectively 835 NSCLC patients. Three hundred and thirty-five of them with bone metastasis were included in the study. SREs and the other prognostic factors were evaluated by univariate and multivariate analysis for SRE-free survival and OS. SREs were detected in 244 patients (72.8 %). The most common SREs were the need for radiotherapy (43.2 %) and malignant hypercalcemia (17.6 %). The median time to first SRE was 3.5 months at the median follow-up of 17 months. A multivariate analysis showed that the presence of bone metastasis at diagnosis (p < 0.001), the number of bone metastasis (p = 0.001), baseline hypercalcemia (p = 0.004), and the presence of palliative radiotherapy (p = 0.04) were independent prognostic factors for SRE-free survival. A logistic regression analysis identified that the presence of bone metastasis at diagnosis [odds ratio (OR), 12.6], number of bone metastasis (OR, 3.05), and baseline hypercalcemia (OR, 0.33) were found to be predictive factors in the developing of SRE. The median OS time for patients with SRE was worse than that for patients without SRE (7 vs 12 months, respectively). For OS, male gender, ECOG performance status (PS), high lactate dehydrogenase (LDH) level, hypoalbuminemia, the presence of bone metastasis at diagnosis, the number of bone metastasis, the presence of SREs, the presence of bisphosphonate therapy, and palliative radiotherapy were independent prognostic indicators for OS by the multivariate analysis. Our results indicated that the frequency of SREs was high and the presence of bone metastasis at the time of diagnosis, baseline hypercalcemia, and multiple bone metastases were significant factors predicting the occurrence of SREs. If bone metastases diagnose earlier, treatments for the prevention of SREs may be initiated earlier; thus, the deterioration of quality of life may be preserved.
dc.identifier.citationUlaş, A., Bilici, A., Durnalı, A., Tokluoğlu, S., Akıncı, S., Silay, K. ... Alkış, N. (2016). Risk factors for skeletal-related events (SREs) and factors affecting SRE-free survival for nonsmall cell lung cancer patients with bone metastases. Tumor Biology, 37(1), 1131-1140. https://dx.doi.org/10.1007/s13277-015-3907-z
dc.identifier.doi10.1007/s13277-015-3907-z
dc.identifier.endpage1140
dc.identifier.issn1010-4283
dc.identifier.issn1423-0380
dc.identifier.issue1
dc.identifier.scopusqualityQ1
dc.identifier.startpage1131
dc.identifier.urihttps://dx.doi.org/10.1007/s13277-015-3907-z
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3866
dc.identifier.volume37
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Ltd
dc.relation.ispartofTumor Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSkeletal-Free Events
dc.subjectSRE-Free Survival
dc.subjectNonsmall Cell Lung Cancer
dc.subjectBone Metastases
dc.titleRisk factors for skeletal-related events (SREs) and factors affecting SRE-free survival for nonsmall cell lung cancer patients with bone metastases
dc.typeArticle

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