Risk assessment for arrhythmia in pediatric renal transplant recipients

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dc.authorid0000-0002-3582-5075
dc.contributor.authorKasap Demir, Belde
dc.contributor.authorSoyaltın, Eren
dc.contributor.authorAlparslan, Caner
dc.contributor.authorArslansoyu Çamlar, Seçil
dc.contributor.authorDemircan, Tülay
dc.contributor.authorYavaşcan, Önder
dc.contributor.authorMutlubaş, Fatma
dc.contributor.authorAlaygut, Demet
dc.contributor.authorKaradeniz, Cem
dc.date.accessioned2023-04-04T12:52:35Z
dc.date.available2023-04-04T12:52:35Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractObjectives: Renal transplant recipients are at risk for ventricular arrhythmia and sudden death. To assess that risk, we compared the ventricular repolarization markers of pediatric renal transplant recipients with those of healthy children. Materials and Methods: We included 30 children and adolescents who were followed for at least 6 months after renal transplant; 30 age- and sex-matched children were included for the control group. Demographic features, medications, and laboratory findings were recorded. Blood pressure measurements, ventricular repolarization indexes including QT dispersion, corrected QT dispersion, T-wave peak-to-end interval dispersion, the T-wave peak-to-end interval/QT ratio, the T-wave peak-to-end interval/corrected QT ratio, left ventricular mass index, and relative wall thickness were compared between groups. In addition, the correlations of ventricular repolarization indexes with other variables were evaluated. Results: Blood pressure standard deviation scores, the mean heart rate, QT dispersion, corrected QT dispersion, the T-wave peak-to-end interval/QT ratio, the T-wave peak-to-end interval/corrected QT ratio, left ventricular mass index, and relative wall thickness values were significantly higher in renal transplant patients, whereas T-wave peak-to-end interval dispersion, ejection fraction, and fractional shortening were similar between groups. Although ventricular repolarization indexes were similar in patients with and without left ventricular hypertrophy, only corrected QT dispersion was significantly higher in patients with hypertension (P = .006). The only variable that significantly predicted prolonged corrected QT dispersion was the systolic blood pressure standard deviation score (P = .005, beta = .403). Conclusions: Ventricular repolarization anomalies, hypertension, left ventricular hypertrophy, and cardiac geometry irregularity may be observed after renal transplant in pediatric recipients despite acceptable allograft functions and normal serum electrolyte levels. Control of systolic blood pressure would decrease the risk of ventricular repolarization abnormalities, namely, the corrected QT dispersion. Follow-up of cardiovascular risks with noninvasive methods is recommended in all pediatric renal transplant recipients.
dc.identifier.citationKasap Demir, B., Soyaltın, E., Alparslan, C., Arslansoyu Çamlar, S., Demircan, T., Yavaşcan, Ö. ... Karadeniz, C. (2023). Risk assessment for arrhythmia in pediatric renal transplant recipients. Experimental and Clinical Transplantation, 21(1), 28-35. https://dx.doi.org/10.6002/ect.2020.0162
dc.identifier.doi10.6002/ect.2020.0162
dc.identifier.endpage35
dc.identifier.issn1304-0855
dc.identifier.issn2146-8427
dc.identifier.issue1
dc.identifier.pmid33535941
dc.identifier.startpage28
dc.identifier.urihttps://dx.doi.org/10.6002/ect.2020.0162
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10798
dc.identifier.volume21
dc.identifier.wos000945733200005en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorYavaşcan, Önder
dc.language.isoen
dc.publisherBaşkent University
dc.relation.ispartofExperimental and Clinical Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectVentricular Repolarization
dc.subjectBlood Pressure
dc.subjectChildren
dc.titleRisk assessment for arrhythmia in pediatric renal transplant recipients
dc.typeArticle

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