The effects of tacrolimus on the activity and expression of tissue factor in the rat ovary with ischemia-reperfusion induced injury

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dc.authorid0000-0002-7059-1884
dc.contributor.authorÜstündağ, Ünsal Veli
dc.contributor.authorŞahin, Sadık
dc.contributor.authorAk, Koray
dc.contributor.authorKeskin, İlknur
dc.contributor.authorEmekli Alturfan, Ebru
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:51Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:51Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.descriptionWOS: 000362463000002
dc.descriptionPubMed ID: 26370456
dc.description.abstractIn the present study, the effects of tacrolimus on the activity and expression of tissue factor (TF) were investigated in the ovarian ischemia-reperfusion induced injury in rats. Twenty-eight female rats (8-12 weeks, 300-350 g) were divided into four groups: control, ischemia-reperfusion (IR), tacrolimus treated before ischemia (TBI), and tacrolimus treated before reperfusion (TBR) groups (n = 7/per group). TF activity was measured using Quick's method, whereas TF expression was examined immunohistochemically. TF activity was significantly higher in all treated groups compared with the control group. Strong ovarian TF expression was demonstrated in the IR and TBR groups. Moreover, tacrolimus decreased TF activity in the TBI group compared with the IR group. The decreased activity of TF in the ovarian IR model may prevent IR-related inflammation during transplant procedure. (C) 2015 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn.
dc.description.sponsorshipCommission of Scientific Investigations Projects of Marmara University (Turkey) [SAG-C-YLP-120613-0240]en_US
dc.description.sponsorshipThis study was financially supported by Grant Project No: SAG-C-YLP-120613-0240 from the Commission of Scientific Investigations Projects of Marmara University (Turkey).en_US
dc.identifier.citationÜstündağ, Ü. V., Şahin, S., Ak, K., Keskin, İ. ve Emekli Alturfan, E. (2015). The effects of tacrolimus on the activity and expression of tissue factor in the rat ovary with ischemia-reperfusion induced injury. Reproductive Biology, 15(3), 139-145. https://dx.doi.org/10.1016/j.repbio.2015.07.002
dc.identifier.doi10.1016/j.repbio.2015.07.002
dc.identifier.endpage145
dc.identifier.issn1642-431X
dc.identifier.issue3
dc.identifier.scopusqualityQ1
dc.identifier.startpage139
dc.identifier.urihttps://dx.doi.org/10.1016/j.repbio.2015.07.002
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3748
dc.identifier.volume15
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInstitute of Animal Reproduction and Food Research
dc.relation.ispartofReproductive Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectTacrolimus
dc.subjectTissue Factor
dc.subjectOvary
dc.subjectIschemia Reperfusion
dc.titleThe effects of tacrolimus on the activity and expression of tissue factor in the rat ovary with ischemia-reperfusion induced injury
dc.typeArticle

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