Treatment effects on event-related EEG potentials and oscillations in Alzheimer's disease

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dc.authorid0000-0002-7715-3035
dc.authorid0000-0002-7555-3801
dc.authorid0000-0002-0860-0524
dc.contributor.authorYener, Görsev
dc.contributor.authorHünerli Gündüz, Duygu
dc.contributor.authorYıldırım, Ebru
dc.contributor.authorAktürk, Tuba
dc.contributor.authorBaşar Eroğlu, Canan
dc.contributor.authorBonanni, Laura
dc.contributor.authorDel Percio, Claudio
dc.contributor.authorFarina, Francesca
dc.contributor.authorFerri, Raffaele
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorHajós, Mihály
dc.contributor.authorIbáñez, Agustín
dc.contributor.authorJiang, Yang
dc.contributor.authorLizio, Roberta
dc.contributor.authorLopez, Susanna
dc.contributor.authorNoce, Giuseppe
dc.contributor.authorParra, Mario A.
dc.contributor.authorRandall, Fiona
dc.contributor.authorStocchi, Fabrizio
dc.contributor.authorBabiloni, Claudio
dc.date.accessioned2022-06-17T06:47:22Z
dc.date.available2022-06-17T06:47:22Z
dc.date.issued2022
dc.departmentİstanbul Medipol Üniversitesi, İMÜ Meslek Yüksekokulu, Elektronörofizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Sinirbilim Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı
dc.description.abstractAlzheimer's disease dementia (ADD) is the most diffuse neurodegenerative disorder belonging to mild cognitive impairment (MCI) and dementia in old persons. This disease is provoked by an abnormal accumulation of amyloid-beta and tauopathy proteins in the brain. Very recently, the first disease-modifying drug has been licensed with reserve (i.e., Aducanumab). Therefore, there is a need to identify and use biomarkers probing the neurophysiological underpinnings of human cognitive functions to test the clinical efficacy of that drug. In this regard, event-related electroencephalographic potentials (ERPs) and oscillations (EROs) are promising candidates. Here, an Expert Panel from the Electrophysiology Professional Interest Area of the Alzheimer's Association and Global Brain Consortium reviewed the field literature on the effects of the most used symptomatic drug against ADD (i.e., Acetylcholinesterase inhibitors) on ERPs and EROs in ADD patients with MCI and dementia at the group level. The most convincing results were found in ADD patients. In those patients, Acetylcholinesterase inhibitors partially normalized ERP P300 peak latency and amplitude in oddball paradigms using visual stimuli. In these same paradigms, those drugs partially normalize ERO phase-locking at the theta band (4–7 Hz) and spectral coherence between electrode pairs at the gamma (around 40 Hz) band. These results are of great interest and may motivate multicentric, double-blind, randomized, and placebo-controlled clinical trials in MCI and ADD patients for final cross-validation.
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USAen_US
dc.identifier.citationYener, G., Hünerli Gündüz, D., Yıldırım, E., Aktürk, T., Başar Eroğlu, C., Bonanni, L. ... Babiloni, C. (2022). Treatment effects on event-related EEG potentials and oscillations in Alzheimer's disease. International Journal of Psychophysiology, 177, 179-201. http://doi.org/10.1016/j.ijpsycho.2022.05.008
dc.identifier.doi10.1016/j.ijpsycho.2022.05.008
dc.identifier.endpage201
dc.identifier.issn0167-8760
dc.identifier.issn1872-7697
dc.identifier.pmid35588964
dc.identifier.scopus2-s2.0-85131441990
dc.identifier.scopusqualityQ2
dc.identifier.startpage179
dc.identifier.urihttp://doi.org/10.1016/j.ijpsycho.2022.05.008
dc.identifier.urihttps://hdl.handle.net/20.500.12511/9528
dc.identifier.volume177
dc.identifier.wos000808370700005en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYıldırım, Ebru
dc.institutionauthorAktürk, Tuba
dc.institutionauthorGüntekin, Bahar
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofInternational Journal of Psychophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAlzheimer
dc.subjectBiomarker
dc.subjectDementia
dc.subjectEEG
dc.subjectEROs
dc.subjectERPs
dc.subjectEvent-related
dc.subjectMild Cognitive Impairment
dc.subjectMonitoring
dc.subjectOscillations
dc.subjectP300
dc.subjectTreatment
dc.titleTreatment effects on event-related EEG potentials and oscillations in Alzheimer's disease
dc.typeArticle

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