Capecitabine-cisplatin versus 5-fluorouracil/leucovorin in combination with radiotherapy for adjuvant therapy of lymph node positive locally advanced gastric cancer

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dc.contributor.authorÖven Ustaalioğlu, Bala Başak
dc.contributor.authorBilici, Ahmet
dc.contributor.authorTilki, Metin
dc.contributor.authorSürmelioğlu, Ali
dc.contributor.authorErkol, Burçak
dc.contributor.authorFigen, Metin
dc.contributor.authorUyar, Serab
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:14Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:14Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000445690700030
dc.descriptionPubMed ID: 30249896
dc.description.abstractAim of the Study: Although surgery is considered to be curative treatment, recurrence rates are high in gastric cancer. Adjuvant 5-fluorouracil (5-FU) based chemoradiotherapy has been shown to improve the prognosis. We compared tolerability and efficacy of the two different chemotherapy regimens; 5-FU/leucovorin (LV) versus cisplatin with capecitabine (XP) combined with radiotherapy (RT) in the adjuvant therapy of the lymph node positive locally advanced gastric cancer. Materials and Methods: Totally, 104 patients who underwent curative surgery with lymph node resection were evaluated, respectively. Patients were stratified two group based on the adjuvant chemoradiotherapy regimen. Group 1 (n = 46) received XP followed capecitabine with RT (XRT) then XP. Group 2 (n = 58) received 5-FU/LV combined with RT postoperatively. Two groups were compared based on clinicopathological parameters. Factors related with disease-free survival (DFS) and overall survival (OS) were analyzed. Results: Totally, 32 patients had recurrent disease, and there was no difference between two groups. While peritoneal metastasis was more common in XP arm, distant metastasis was commonly seen in 5-FU/LV arm. There was no significant difference between two groups in regard of Grade 3/4 toxicitis; hematologic toxicities were more in 5-FU/LV group than XP arm. In addition, dose modification because of toxicities were more frequent in 5-FU/LV arm (P = 0.003). For all groups, lymph node dissection type was related with DFS, surgical margin and recurrence were important for OS. Conclusion: XP-XRT regimen is well tolerated with lower toxicity compared the standard 5-FU/LV-RT. Although there is no difference with respect to outcome, patients with XP arm without the necessity of intravenous catheter admitted hospital less frequent than bolus5-FU/LV arm.
dc.identifier.citationÖven Ustaalioğlu, B. B., Bilici, A., Tilki, M., Sürmelioğlu, A., Erkol, B., Figen, M. ... Uyar, S. (2018). Capecitabine-cisplatin versus 5-fluorouracil/leucovorin in combination with radiotherapy for adjuvant therapy of lymph node positive locally advanced gastric cancer. Journal of Cancer Research and Therapeutics, 14(Supplement: 3), S736-S741. https://dx.doi.org/10.4103/0973-1482.183548
dc.identifier.doi10.4103/0973-1482.183548
dc.identifier.endpageS741
dc.identifier.issn0973-1482
dc.identifier.issn1998-4138
dc.identifier.issueSupplement: 3
dc.identifier.scopusqualityQ3
dc.identifier.startpageS736
dc.identifier.urihttps://dx.doi.org/10.4103/0973-1482.183548
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1922
dc.identifier.volume14
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofJournal of Cancer Research and Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectAdjuvant Chemoradiotherapy
dc.subjectCapecitabine
dc.subjectGastric Cancer
dc.subjectLymph Node Positive
dc.subject5-Fluorouracil / Leucovorin
dc.titleCapecitabine-cisplatin versus 5-fluorouracil/leucovorin in combination with radiotherapy for adjuvant therapy of lymph node positive locally advanced gastric cancer
dc.typeArticle

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