The biocompatibility of a ginger-containing herbal toothpaste on developing zebrafiish embryos

Basit Öğe Kaydı
dc.authorid0000-0003-0804-1475
dc.contributor.authorMeşeli, Simge
dc.contributor.authorÜstündağ, Ünsal Veli
dc.contributor.authorAteş, Perihan Seda
dc.contributor.authorÜnal, İsmail
dc.contributor.authorIşık Alturfan, Ebru
dc.date.accessioned2023-10-31T10:22:06Z
dc.date.available2023-10-31T10:22:06Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractThe biocompatibility of toothpaste in an oral cavity should be approved by clinical trials. Nowadays, herbal toothpaste is increasing in popularity due to its natural ingredients. Being genetically similar to humans, zebrafish are used in potential toxicity testing. The zebrafish embryotoxicity test is a fast and straightforward method to study chemical toxicity during embryogenesis. Objective: This study aimed to evaluate if there was any biocompatibility of the toothpaste on zebrafish embryos. Methods: Adult AB strain zebrafish were used according to Institutional Animal Care and Use Committee protocols. Normally dividing, spherical embryos were exposed to herbal toothpaste with ginger (Gumgumix, Turkey) (50 mg/L) and conventional toothpaste (Signal, Expert Protection, Bulgaria) (50 mg/L) in well plates containing 20 embryos, having four replicates. Developmental effects, mortality, and hatching rates were evaluated for 72h. Results: Zebrafish embryos exposed to conventional toothpaste had a higher mortality rate than those exposed to herbal toothpaste; they hatched later and delayed in development. There was no difference between herbal toothpaste and the control group regarding mortality and hatching rates (p > 0.005). Conclusion: The herbal toothpaste showed higher biocompatibility on zebrafish embryos compared to the conventional toothpaste under the condition of this study.
dc.identifier.citationMeşeli, S., Üstündağ, Ü. V., Ateş, P. S., Ünal, İ. ve Işık Alturfan, E. (2023). The biocompatibility of a ginger-containing herbal toothpaste on developing zebrafiish embryos. Journal of Dentistry Indonesia, 30(2), 115-120. https://dx.doi.org/10.14693/jdi.v30i2.1437
dc.identifier.doi10.14693/jdi.v30i2.1437
dc.identifier.endpage120
dc.identifier.issn1693-9697
dc.identifier.issn2355-4800
dc.identifier.issue2
dc.identifier.startpage115
dc.identifier.urihttps://dx.doi.org/10.14693/jdi.v30i2.1437
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11676
dc.identifier.volume30
dc.identifier.wos001080804000006en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.institutionauthorÜstündağ, Ünsal Veli
dc.language.isoen
dc.publisherUniversitas Indonesia
dc.relation.ispartofJournal of Dentistry Indonesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDevelopment
dc.subjectEmbryo
dc.subjectToothpaste
dc.subjectToxicity
dc.subjectZebrafish
dc.titleThe biocompatibility of a ginger-containing herbal toothpaste on developing zebrafiish embryos
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Ustundag-Unsal-2023.pdf
Boyut:
689.84 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Makale Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu