Comparison of cellular immunity in patients with chronic hepatitis B, inactive hepatitis B surface antigen carriers and spontaneously recovered individuals

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dc.authorid0000-0001-8554-7651
dc.authorid0000-0001-8945-2385
dc.contributor.authorArslan, Ferhat
dc.contributor.authorMert, Ali
dc.contributor.authorSili, Uluhan
dc.contributor.authorTabak, Fehmi
dc.contributor.authorÖztürk, Recep
dc.contributor.authorÖzaras, Reşat
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:56:11Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:56:11Z
dc.date.issued2014
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı
dc.descriptionWOS: 000346326500036
dc.descriptionPubMed ID: 25699376
dc.description.abstractDifferent clinical outcomes of acute HBV infection have been partially explained by individual differences in immune response. In this study We investigated interferon gamma (IFN-gamma) secretion of peripheral blood mononuclear cells (PBMC) in vitro against specific (Hepatitis B core antigen; recombinant HBcAg) and non-specific (CMV, EBV, Influenza peptide pool; CTL CFF peptide pool "plus") antigens using enzyme linked immunospot (ELISPOT) assay in 7 patients with chronic hepatitis B (CHB group), 8 inactive carriers of HBV (carrier group) and 8 subjects who spontaneously recovered from acute HBV infection as detected by anti-HBs positivity (immune group). Phytohemaglutinin served as the positive test control. Response against recombinant HBcAg was 88 +/- 35, 50 +/- 110, 105 +/- 150 spot forming cell (SFC) /10(5) PBMC, in CHB, carrier and immune groups, respectively. HBeAg-specific T-cell response was slightly higher in the immune group; however, statistically there was no significant difference between the groups. Assessment of cellular immunity by IFN-gamma ELISPOT was not sufficient to explain the various outcomes of HBV infection such as resolution, chronicity and carriership.
dc.identifier.citationArslan, F., Mert, A., Sili, U., Tabak, F., Öztürk, R. ve Özaras, R. (2014). Comparison of cellular immunity in patients with chronic hepatitis B, inactive hepatitis B surface antigen carriers and spontaneously recovered individuals. Hepato-Gastroenterology, 61(136), 2326-2329.
dc.identifier.doi10.5754/hge13891
dc.identifier.endpage2329
dc.identifier.issn0172-6390
dc.identifier.issue136
dc.identifier.scopusqualityQ2
dc.identifier.startpage2326
dc.identifier.urihttps://hdl.handle.net/20.500.12511/2612
dc.identifier.volume61
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherH G E Update Medical Publishing S A
dc.relation.ispartofHepato-Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectChronic Hepatitis B
dc.subjectELISPOT Assay
dc.subjectInterferon Gamma
dc.titleComparison of cellular immunity in patients with chronic hepatitis B, inactive hepatitis B surface antigen carriers and spontaneously recovered individuals
dc.typeArticle

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