Resting-state electroencephalographic delta rhythms may reflect global cortical arousal in healthy old seniors and patients with Alzheimer's disease dementia

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dc.authorid0000-0002-0860-0524
dc.authorid0000-0002-7555-3801
dc.authorid0000-0003-4292-5717
dc.contributor.authorBabiloni, Claudio
dc.contributor.authorFerri, Raffaele
dc.contributor.authorNoce, Giuseppe
dc.contributor.authorLizio, Roberta
dc.contributor.authorLopez, Susanna
dc.contributor.authorSoricelli, Andrea
dc.contributor.authorNobili, Flavio
dc.contributor.authorArnaldi, Dario
dc.contributor.authorFama, Francesco
dc.contributor.authorOrzi, Francesco
dc.contributor.authorButtinelli, Carla
dc.contributor.authorGiubilei, Franco
dc.contributor.authorCipollini, Virginia
dc.contributor.authorMarizzoni, Moira
dc.contributor.authorGüntekin, Bahar
dc.contributor.authorAktürk, Tuba
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorYener, Görsev
dc.contributor.authorEmek Savaş, Derya Durusu
dc.contributor.authorStocchi, Fabrizio
dc.contributor.authorVacca, Laura
dc.contributor.authorFrisoni, Giovanni B.
dc.contributor.authorDel Percio, Claudio
dc.date.accessioned2021-01-07T10:06:54Z
dc.date.available2021-01-07T10:06:54Z
dc.date.issued2020
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı
dc.description.abstractExtending Basar's theory of event-related EEG oscillations, here we hypothesize that even in quiet wakefulness, transient increases in delta rhythms may enhance global cortical arousal as revealed by the desynchronization of alpha rhythms in normal (Nold) seniors with some derangement in Alzheimer's disease dementia (ADD).Clinical and EEG datasets in 100 ADD and 100 Nold individuals matched as demography, education, and gender were taken from an international archive. Standard delta (< 4 Hz) and alpha1 (8-10.5 Hz) bands were used for the main analysis, while alpha2 (10.5-13 Hz), theta (4-8 Hz), beta1 (13-20 Hz), beta2 (20-35 Hz), and gamma (35-40 Hz) served as controls. In the interpretation, the higher the alpha1 power (density), the lower that arousal. As expected, when compared to the Nold group, the ADD group showed higher global (scalp) power density at the delta-theta band and lower global power density at the alpha-beta bands. As novel findings, we observed that: (1) in the Nold group, the global delta and alpha1-2 power were negatively and linearly correlated; (2) in the ADD group, this correlation was just marginal; and (3) in both Nold and AD groups, the EEG epochs with the highest delta power (median value for stratification) were associated with the lowest global alpha1 power. This effect was related to eLORETA freeware solutions showing maximum alpha1 source activations in posterior cortical regions.These results suggest that even in quiet wakefulness, delta and alpha rhythms are related to each other, and ADD partially affects this cross-band neurophysiological mechanism.
dc.description.sponsorshipMinistry of Health, Italy ; Ministry of Health Italy - Ricerca Corrente (MOH-RC) ; H2020 Marie S. Curie ITN-ETN project with the short title "BBDiag" ; H2020-TWINN-2015 project with the short title "SynaNet"en_US
dc.identifier.citationBabiloni, C., Ferri, R., Noce, G., Lizio, R., Lopez, S., Soricelli, A. ... Del Percio, C. (2020). Resting-state electroencephalographic delta rhythms may reflect global cortical arousal in healthy old seniors and patients with Alzheimer's disease dementia. International Journal of Psychophysiology, 158, 259-270. https://dx.doi.org/10.1016/j.ijpsycho.2020.08.012
dc.identifier.doi10.1016/j.ijpsycho.2020.08.012
dc.identifier.endpage270
dc.identifier.issn0167-8760
dc.identifier.issn1872-7697
dc.identifier.scopusqualityQ2
dc.identifier.startpage259
dc.identifier.urihttps://dx.doi.org/10.1016/j.ijpsycho.2020.08.012
dc.identifier.urihttps://hdl.handle.net/20.500.12511/6198
dc.identifier.volume158
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInternational Journal of Psychophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectResting State Electroencephalographic (rsEEG) Rhythms
dc.subjectDelta Rhythms
dc.subjectAlzheimer's Disease Dementia (ADD)
dc.subjectExact Low Resolution Brain Electromagnetic Source Tomography (eLORETA)
dc.titleResting-state electroencephalographic delta rhythms may reflect global cortical arousal in healthy old seniors and patients with Alzheimer's disease dementia
dc.typeArticle

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