Metaproteogenomic analysis of saliva samples from Parkinson's disease patients with cognitive impairment

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dc.authorid0000-0001-5162-2000
dc.authorid0000-0002-1173-1701
dc.authorid0000-0001-7566-1063
dc.authorid0000-0003-4292-5717
dc.authorid0000-0002-2752-1223
dc.contributor.authorArıkan, Muzaffer
dc.contributor.authorKahraman Demir, Tuğçe
dc.contributor.authorYıldız, Zeynep
dc.contributor.authorNalbantoğlu, Özkan Ufuk
dc.contributor.authorKorkmaz, Nur Damla
dc.contributor.authorHelvacı Yılmaz, Nesrin
dc.contributor.authorŞen, Aysu
dc.contributor.authorÖzcan, Mutlu
dc.contributor.authorMuth, Thilo
dc.contributor.authorHanoğlu, Lütfü
dc.contributor.authorYıldırım, Süleyman
dc.date.accessioned2023-12-15T07:24:45Z
dc.date.available2023-12-15T07:24:45Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Sinirbilim Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractCognitive impairment (CI) is very common in patients with Parkinson's Disease (PD) and progressively develops on a spectrum from mild cognitive impairment (PD-MCI) to full dementia (PDD). Identification of PD patients at risk of developing cognitive decline, therefore, is unmet need in the clinic to manage the disease. Previous studies reported that oral microbiota of PD patients was altered even at early stages and poor oral hygiene is associated with dementia. However, data from single modalities are often unable to explain complex chronic diseases in the brain and cannot reliably predict the risk of disease progression. Here, we performed integrative metaproteogenomic characterization of salivary microbiota and tested the hypothesis that biological molecules of saliva and saliva microbiota dynamically shift in association with the progression of cognitive decline and harbor discriminatory key signatures across the spectrum of CI in PD. We recruited a cohort of 115 participants in a multi-center study and employed multi-omics factor analysis (MOFA) to integrate amplicon sequencing and metaproteomic analysis to identify signature taxa and proteins in saliva. Our baseline analyses revealed contrasting interplay between the genus Neisseria and Lactobacillus and Ligilactobacillus genera across the spectrum of CI. The group specific signature profiles enabled us to identify bacterial genera and protein groups associated with CI stages in PD. Our study describes compositional dynamics of saliva across the spectrum of CI in PD and paves the way for developing non-invasive biomarker strategies to predict the risk of CI progression in PD.
dc.description.sponsorshipFEMS Research and Training Granten_US
dc.identifier.citationArıkan, M., Kahraman Demir, T., Yıldız, Z., Nalbantoğlu, Ö. U., Korkmaz, N. D., Helvacı Yılmaz, N. ... Yıldırım, S. (2023). Metaproteogenomic analysis of saliva samples from Parkinson's disease patients with cognitive impairment. npj Biofilms and Microbiomes, 9(1). https://dx.doi.org/10.1038/s41522-023-00452-x
dc.identifier.doi10.1038/s41522-023-00452-x
dc.identifier.issn2055-5008
dc.identifier.issue1
dc.identifier.pmid37980417
dc.identifier.scopus2-s2.0-85176923983
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.1038/s41522-023-00452-x
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12010
dc.identifier.volume9
dc.identifier.wos001108084600001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorArıkan, Muzaffer
dc.institutionauthorKorkmaz, Nur Damla
dc.institutionauthorHelvacı Yılmaz, Nesrin
dc.institutionauthorHanoğlu, Lütfü
dc.institutionauthorYıldırım, Süleyman
dc.language.isoen
dc.publisherNature Portfolio
dc.relation.ispartofnpj Biofilms and Microbiomesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/315S301
dc.rightsAttribution 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectParkinson's Disease
dc.subjectMetaproteogenomic Analysis
dc.subjectSaliva Samples
dc.titleMetaproteogenomic analysis of saliva samples from Parkinson's disease patients with cognitive impairment
dc.typeArticle

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