Does smoking influence tryptophan metabolism in periodontal inflammation? A cross-sectional study

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dc.authorid0000-0003-1323-4511
dc.contributor.authorÖnder, Canan
dc.contributor.authorAkdoğan, Nihan
dc.contributor.authorKurgan, Şivge
dc.contributor.authorBalcı, Nur
dc.contributor.authorSerdar, Ceyhan Ceran
dc.contributor.authorCeran Serdar, Ceyhan
dc.contributor.authorSerdar, Muhittin Abdulkadir
dc.contributor.authorGünhan, Meral
dc.date.accessioned2024-01-11T12:55:23Z
dc.date.available2024-01-11T12:55:23Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Ana Bilim Dalı
dc.description.abstractObjectivesThe aim of this study was to identify the effects of smoking and periodontal inflammation on tryptophan-kynurenine metabolism as well as the correlation between these findings and clinical periodontal parameters. BackgroundIt has been shown that the tryptophan amino acid's primary catabolic pathway, the kynurenine pathway (KP), may serve as a key biomarker for periodontal disease. Although there are studies investigating the effect of smoking on KYN-TRP metabolism, the effect of smoking on periodontal disease through KP has not been revealed so far. MethodsThe salivary and serum samples were gathered from 24 nonsmoker (NS-P) stage III, grade B generalized periodontitis and 22 smoker (S-P) stage III, grade C generalized periodontitis patients, in addition to 24 nonsmoker (NS-C) and 24 smoker (S-C) periodontally healthy control individuals. Saliva and serum IL-6, kynurenine (KYN), and tryptophan (TRP) values, and KYN/TRP ratio were analyzed by liquid chromatography-mass spectrometry. Clinical periodontal measurements were recorded. ResultsSalivary TRP values were significantly higher in both periodontitis groups than control groups (p < .05). Salivary KYN values were highest in NS-P group (p < .05). Salivary KYN values did not differ significantly between periodontitis groups (p = .84). Salivary KYN/TRP ratio was significantly lower in NS-P group compared to other groups (p < .001). Serum TRP value is higher in S-P group than other groups; however, significant difference was found in S-C group (p < .05). Serum KYN values were significantly lower in smokers than nonsmokers. Serum KYN/TRP ratio is higher in NS-P group. NS-P group has the highest salivary IL-6 levels, NS-C group has the lowest values (p < .05). ConclusionsOur results point out that smoking exacerbates inflammation in the periodontium and increases TRP destruction and decreases IDO activity by suppressing KP in serum. As a result, kynurenine and its metabolites may be significant biomarkers in the link between smoking and periodontal disease.
dc.identifier.citationÖnder, C., Akdoğan, N., Kurgan, Ş., Balcı, N., Serdar, C. C., Ceran Serdar, C. ... Günhan, M. (2023). Does smoking influence tryptophan metabolism in periodontal inflammation? A cross-sectional study. Journal of Periodontal Research, 58(5), 1041-1051. https://dx.doi.org/10.1111/jre.13166
dc.identifier.doi10.1111/jre.13166
dc.identifier.endpage1051
dc.identifier.issn0022-3484
dc.identifier.issn1600-0765
dc.identifier.issue5
dc.identifier.pmid37526075
dc.identifier.scopus2-s2.0-85166558494
dc.identifier.scopusqualityQ1
dc.identifier.startpage1041
dc.identifier.urihttps://dx.doi.org/10.1111/jre.13166
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12128
dc.identifier.volume58
dc.identifier.wos001040480300001en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBalcı, Nur
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofJournal of Periodontal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-NoDerivs 4.0 International*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectKynurenine Pathway
dc.subjectPeriodontitis
dc.subjectSmoking
dc.titleDoes smoking influence tryptophan metabolism in periodontal inflammation? A cross-sectional study
dc.typeArticle

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