Neuropsychiatric outcomes and caregiver distress in primary progressive aphasia

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dc.authorid0000-0002-2306-5937
dc.contributor.authorSeçkin, Mustafa
dc.contributor.authorYıldırım, Elif
dc.contributor.authorDemir, İlayda
dc.contributor.authorOrhun, Ömer
dc.contributor.authorBülbül, Ezgi
dc.contributor.authorVelioğlu, Halil Aziz
dc.contributor.authorÖktem, Öget
dc.contributor.authorYeşilot, Nilüfer
dc.contributor.authorÇoban, Oğuzhan
dc.contributor.authorGürvit, Hakan
dc.date.accessioned2023-02-23T08:08:38Z
dc.date.available2023-02-23T08:08:38Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü
dc.description.abstractBackground: In this study, we aimed to outline the neuropsychiatric consequences of primary progressive aphasia (PPA) and to understand how neuropsychiatric symptomatology affects distress in caregivers. Methods: The Neuropsychiatric Inventory (NPI) including the distress index (NPI-Distress) was used. Additional information about the caregiver burden was obtained using Zarit Burden Interview (ZBI). NPI, NPI-Distress, and ZBI data from 17 patients with a clinical diagnosis of PPA were compared with 10 stroke aphasia patients. Neuropsychiatric symptomatology was investigated based on three clusters; Mood, Frontal/Comportmental, and Psychotic/Disruptive. Additionally, the Activities of Daily Living Questionnaire (ADLQ) was used to outline the functional impairment. Twelve healthy controls were included to compare the neurocognitive test scores with PPA and stroke aphasia groups. Results: A greater number of neuropsychiatric symptoms were observed in the PPA group compared to the stroke aphasia group. The number of symptoms in Mood, and Frontal/Comportmental clusters were greater than the number of symptoms in Psychotic/Disruptive clusters in the PPA group, whereas no significant relationship between the number of symptoms and symptom clusters was found in the stroke aphasia group. In the PPA group, a strong correlation was found between the NPI-Frequency × Severity scores and the NPI-Distress scores. Moreover, the NPI-Distress scores in the PPA group strongly correlated with the ZBI scores. Scores for anxiety, irritability/lability, and apathy had a stronger correlation with the NPI-Distress scores compared to the other NPI symptoms. The Communication subscale was the most impaired domain in the PPA group. Travel, and Employment and Recreation subscales showed greater functional impairment in the stroke aphasia group compared to the PPA group. Conclusions: Neuropsychiatric symptoms in PPA in our study were more frequent than previously reported. Furthermore, the distress index of the NPI was not only correlated with the severity of the neuropsychiatric symptoms but also reflected the overall burden on the caregivers in the PPA group.
dc.description.sponsorshipEuropean Commission ; Brain Circulation Schemeen_US
dc.identifier.citationSeçkin, M., Yıldırım, E., Demir, İ., Orhun, Ö., Bülbül, E., Velioğlu, H. A. ... Gürvit, H. (2023). Neuropsychiatric outcomes and caregiver distress in primary progressive aphasia. Psychogeriatrics, 23(1), 52-62. https://doi.org/10.1111/psyg.12902
dc.identifier.doi10.1111/psyg.12902
dc.identifier.endpage62
dc.identifier.issn1346-3500
dc.identifier.issn1479-8301
dc.identifier.issue1
dc.identifier.pmid36273493
dc.identifier.scopus2-s2.0-85140223931
dc.identifier.scopusqualityQ2
dc.identifier.startpage52
dc.identifier.urihttps://doi.org/10.1111/psyg.12902
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10515
dc.identifier.volume23
dc.identifier.wos000871422800001en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorVelioğlu, Halil Aziz
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofPsychogeriatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectBehaviour
dc.subjectCaregiver Burden
dc.subjectNeuropsychiatric Inventory
dc.subjectPrimary Progressive Aphasia
dc.subjectStroke Aphasia
dc.titleNeuropsychiatric outcomes and caregiver distress in primary progressive aphasia
dc.typeArticle

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