Nuclear factor-kappa B expression in the endometrium of normal and overweight women with polycystic ovary syndrome

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dc.contributor.authorKoç, Önder
dc.contributor.authorÖzdemirici, Şafak
dc.contributor.authorAcet, Mustafa
dc.contributor.authorSoytürk, Ümmügülsüm
dc.contributor.authorAydın, Süleyman
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:58:48Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:58:48Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.descriptionWOS: 000411307000017
dc.descriptionPubMed ID: 28617068
dc.description.abstractThe aim of this study was to investigate whether the expression levels of endometrial NF kappa B p65 differ between normal weight and overweight PCOS women and to compare them with BMI-matched control subjects without PCOS. The study group comprised 20 normal weight (BMI: 18.5-24.9 kg/m(2)) and 15 overweight PCOS women (BMI: 25-29.9 kg/m(2)) with infertility. Healthy fertile women without PCOS were recruited as the control group. The patients in the normal weight PCOS group and control group were age and BMI-matched. Endometrial samples were obtained during the mid-luteal phase for immunohistochemical staining. The H-Score method was used to evaluate NF-kappa B p65 (Rel A) expression. Both normal and overweight PCOS women demonstrated significantly higher endometrial NF-kappa B p65 expression than the women without PCOS. The H-scores of endometrial NF-kappa B p65 expression were similar in both groups of PCOS women. NF-kappa B p65 was positively correlated with serum insulin, HOMA-IR and total testosterone levels in PCOS women. By leading to pathological inflammation, an increase in NF-kappa B p65 expression in the endometrium of normal and overweight PCOS women may contribute to PCOS-related subfertility. IMPACT STATEMENT What is already known on this subject: Although the pathogenesis of PCOS has not yet been clarified, low-grade chronic inflammation is gradually being established as an important pathogenetic factor. Increased levels of inflammatory cytokines such as IL-6 and TNF-alpha. have been reported in women with PCOS. Causes of pathological endometrial inflammation may arise from either a local endometrial disease or linked to diseases which are located in a distant reproductive tissue. Nevertheless, possible role of endometrial NF-kappa B, basic cellular regulatory of inflammation, in the pathophysiology of PCOS related implantation defect has not been elucidated yet. What do the results of this study add: This study provides first and novel insights into the relationship between PCOS related infertility and pathological endometrial inflammation. We demonstrated that there is a close association between PCOS and pathological endometrial inflammation. Moreover, we clearly showed that pathological endometrial inflammation occurs in both normal and overweight women with PCOS. Further, endometrial NF-kappa B p65 (Rel A) expression were found to be positively correlated with serum insulin levels and hyperandrogenism in overweight PCOS women. What are the implications of these findings for clinical practice: If we can analyse pathological endometrial inflammation by measuring endometrial NF-kappa B p65 (Rel A) expression, treatment could be directed towards eliminating the source of pathological endometrial inflammation.
dc.identifier.citationKoç, Ö., Özdemirci, Ş., Acet, M., Soytürk, Ü. ve Aydın, S. (2017). Nuclear factor-kappa B expression in the endometrium of normal and overweight women with polycystic ovary syndrome. Journal of Obstetrics and Gynaecology, 37(7), 924-930. https://dx.doi.org/10.1080/01443615.2017.1315563
dc.identifier.doi10.1080/01443615.2017.1315563
dc.identifier.endpage930
dc.identifier.issn0144-3615
dc.identifier.issn1364-6893
dc.identifier.issue7
dc.identifier.scopusqualityQ3
dc.identifier.startpage924
dc.identifier.urihttps://dx.doi.org/10.1080/01443615.2017.1315563
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3229
dc.identifier.volume37
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd.
dc.relation.ispartofJournal of Obstetrics and Gynaecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPCOS
dc.subjectNuclear Factor Kappa B
dc.subjectEndometrial Inflammation
dc.titleNuclear factor-kappa B expression in the endometrium of normal and overweight women with polycystic ovary syndrome
dc.typeArticle

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