In vitro effects of rabeprazole on human pylorus tone

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dc.authorid0000-0001-7702-2441
dc.contributor.authorYaşar, Necdet Fatih
dc.contributor.authorPolat, Erdal
dc.contributor.authorDuman, Mustafa
dc.contributor.authorDağdelen, Meltem
dc.contributor.authorGünal, Mehmet Yalçın
dc.contributor.authorUzun, Orhan
dc.contributor.authorAkyüz, Cebrail
dc.contributor.authorPeker, Kıvanç Derya
dc.contributor.authorYol, Sinan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:58:40Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:58:40Z
dc.date.issued2015
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.descriptionWOS: 000352750400009
dc.descriptionPubMed ID: 25843074
dc.description.abstractBackground/Aims It has been reported that proton pump inhibitors induce relaxation in different types of smooth muscles. The aim of this study is to investigate in vitro effects of proton pump inhibitors on human pylorus muscle. Methods Pyloric sphincters were studied in 10 patients who were operated for stomach cancer. In isolated organ bath, control and response to rabeprazole were recorded following contraction with carbachol. During the treatment experiment, while distilled water was applied during the control experiment in every 5 minutes, rabeprazole was administered in every 5 minutes at doses of 10(-6), 10(-6), 10(-4), and 10(-3) M respectively. Contraction frequencies, maximum contraction values and muscle tones were measured. Results The contraction frequencies in the control group were greater than the rabeprazole group in the second, third and fourth intervals while the maximum contraction values in the rabeprazole group were lower in the fourth interval. Even though muscles tones were not different in both groups during all intervals, it was remarkable that the muscle tone was significantly decreased in the rabeprazole group during the fourth interval compared to the first and second intervals. Conclusions In the present study, high doses of rabeprazole reduced contraction frequencies, maximum contraction values, and muscle tone of human pylorus.
dc.description.sponsorshipYeditepe Universityen_US
dc.description.sponsorshipThe present study was supported by Yeditepe University. The authors are thankful to Ece Genc, Prof. Dr. for her invaluable mentorship.en_US
dc.identifier.citationYaşar, N. F., Polat, E., Duman, M., Dağdelen, M., Günal, M. Y., Uzun, O. ... Yol, S. (2015). In vitro effects of rabeprazole on human pylorus tone. Journal of Neurogastroenterology and Motility, 21(2), 217-221. https://dx.doi.org/10.5056/jnm14126
dc.identifier.doi10.5056/jnm14126
dc.identifier.endpage221
dc.identifier.issn2093-0879
dc.identifier.issn2093-0887
dc.identifier.issue2
dc.identifier.scopusqualityQ2
dc.identifier.startpage217
dc.identifier.urihttps://dx.doi.org/10.5056/jnm14126
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3210
dc.identifier.volume21
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherThe Korean Society of Neurogastroenterlogy and Motility
dc.relation.ispartofJournal of Neurogastroenterology and Motilityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial 3.0 Unported*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/*
dc.subjectMuscle Tonus
dc.subjectProton Pump Inhibitors
dc.subjectPylorus
dc.subjectRabeprazole
dc.titleIn vitro effects of rabeprazole on human pylorus tone
dc.typeArticle

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