Chemogenetic tools for causal cellular and neuronal biology

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dc.authorid0000-0002-3325-8820
dc.contributor.authorAtasoy, Deniz
dc.contributor.authorSternson, Scott M.
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:02:34Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:02:34Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.descriptionWOS: 000424096200008
dc.descriptionPubMed ID: 29351511
dc.description.abstractChemogenetic technologies enable selective pharmacological control of specific cell populations. An increasing number of approaches have been developed that modulate different signaling pathways. Selective pharmacological control over G protein-coupled receptor signaling, ion channel conductances, protein association, protein stability, and small molecule targeting allows modulation of cellular processes in distinct cell types. Here, we review these chemogenetic technologies and instances of their applications in complex tissues in vivo and ex vivo.
dc.description.sponsorshipEuropean Molecular Biology Organization (EMBO) Installation Grant; Howard Hughes Medical Instituteen_US
dc.description.sponsorshipD. Atasoy is supported by a European Molecular Biology Organization (EMBO) Installation Grant. S. M. Sternson is funded by the Howard Hughes Medical Institute.en_US
dc.identifier.citationAtasoy, D. ve Sternson, S. (2018). Chemogenetic tools for causal cellular and neuronal biology. Physiological Reviews, 98(1), 391-418. https://dx.doi.org/10.1152/physrev.00009.2017
dc.identifier.doi10.1152/physrev.00009.2017
dc.identifier.endpage418
dc.identifier.issn0031-9333
dc.identifier.issn1522-1210
dc.identifier.issue1
dc.identifier.scopusqualityQ1
dc.identifier.startpage391
dc.identifier.urihttps://dx.doi.org/10.1152/physrev.00009.2017
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3679
dc.identifier.volume98
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAmerican Physiological Society
dc.relation.ispartofPhysiological Reviewsen_US
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNeuronal Biology
dc.subjectCausal Cellular
dc.subjectChemogenetic Tools
dc.titleChemogenetic tools for causal cellular and neuronal biology
dc.typeReview Article

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