Prognostic significance of the advanced lung cancer inflammation index in metastatic small cell lung cancer: a retrospective analysis of 96 patients

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dc.contributor.authorÜrün, Müslih
dc.contributor.authorGüner, Gürkan
dc.contributor.authorSezgin, Yasin
dc.contributor.authorUysal, Emre
dc.contributor.authorSakin, Abdullah
dc.contributor.authorKılıçkap, Saadettin
dc.date.accessioned2025-06-17T12:41:27Z
dc.date.available2025-06-17T12:41:27Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: The advanced lung cancer inflammation index (ALI) is regarded as a potential indicator of systemic inflammation. This retrospective study aimed to evaluate the prognostic role of the ALI in 96 patients with advanced small cell lung cancer (SCLC). Material/Methods: This retrospective study included 96 patients who were diagnosed with extensive stage SCLC in a single institution between 2016 and 2022. The formula for ALI is body mass index (kg/m2)×serum albumin (g/dL)/neutrophil to lymphocyte ratio. Patients were divided into low inflammation (ALI ≥32.5) and high inflammation (ALI <32.5) groups. Kaplan-Meier analysis and Cox proportional analysis were conducted to assess the association between the ALI and patient prognosis. Results: Median age was 61 (range: 41-82) years. Median follow-up was 9 months, and median overall survival (OS) was 10 months (95% CI: 7.75-12.45). A lower ALI score (ALI <32.5) was correlated with a poorer OS than was a higher ALI score (median OS 7 months for ALI <32.5 95% CI: 4.6-9.3 vs 15 months for ALI ≥32.5, 95% CI: 10.6-19.3, P<0.001). In the multivariate analysis, ALI score, Eastern Cooperative Oncology Group performance status, brain metastasis, and bone metastasis were identified as independent prognostic factors. Conclusions: ALI score is a substantial predictor of survival in SCLC as in other types of cancer types. Patients with a low ALI score have poorer survival. Assessment of ALI can identify lung cancer patients at high risk of poor prognosis and can be a useful prognostic marker in clinical practice.
dc.identifier.citationÜrün, M., Güner, G., Sezgin, Y., Uysal, E., Sakin, A. ve Kılıçkap, S. (2024). Prognostic significance of the advanced lung cancer inflammation index in metastatic small cell lung cancer: a retrospective analysis of 96 patients. Medical Science Monitor, 30. http://dx.doi.org/10.12659/MSM.945752
dc.identifier.doi10.12659/MSM.945752
dc.identifier.issn1643-3750
dc.identifier.pmid39256975
dc.identifier.scopus2-s2.0-85204097735
dc.identifier.scopusqualityQ2
dc.identifier.urihttp://dx.doi.org/10.12659/MSM.945752
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12974
dc.identifier.volume30
dc.identifier.wosWOS:001338428900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSakin, Abdullah
dc.institutionauthorid0000-0003-2538-8569
dc.language.isoen
dc.relation.ispartofMedical Science Monitor
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectInflammation
dc.subjectLung
dc.subjectLymphocytes
dc.subjectNeutrophils
dc.subjectSmall Cell Lung Carcinoma
dc.titlePrognostic significance of the advanced lung cancer inflammation index in metastatic small cell lung cancer: a retrospective analysis of 96 patients
dc.typeArticle

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