Evaluation of mean platelet volume and platelet distribution width in patients with asymptomatic intermediate carotid artery plaque

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dc.authorid0000-0003-1919-3183
dc.contributor.authorYılmaz, Fatih
dc.contributor.authorKöklü, Erkan
dc.contributor.authorKızılırmak Yılmaz, Filiz
dc.contributor.authorSarıönder Gençer, Elif
dc.contributor.authorAlparslan, Ahmet Şükrü
dc.contributor.authorYıldırımtürk, Özlem
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:35Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:35Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.descriptionWOS: 000394705500006
dc.descriptionPubMed ID: 27714714
dc.description.abstractBackground: Platelets play a significant role in the pathogenesis of atherosclerosis. In atherosclerotic plaques, the risk of plaque rupture is more crucial than the severity of the stenosis they cause. Non-calcified carotid artery plaques are more unstable than calcified plaques, and they are associated with a higher risk of rupture, thromboembolism, and consequently, stroke. Aim: The purpose of the present study is to compare calcified and non-calcified plaques that cause intermediate carotid artery stenosis, with respect to mean platelet volume (MPV) and platelet distribution width (PDW). Methods: A total of 139 asymptomatic patients with 50-70% stenosis of the carotid artery were included in this study. Carotid Doppler ultrasound imaging and computed tomography angiography were performed to divide the carotid artery plaques into two groups as calcified and non-calcified. Patients included in the calcified (n = 73) and non-calcified (n = 66) plaque groups were compared with respect to MPV and PDW. Results: Mean platelet volume was statistically significantly higher in the non-calcified plaque group compared to the calcified plaque group (MPV in non-calcified/calcified plaque groups [fL]: 10.0/9.0, respectively) (p < 0.01). PDW was not significantly different between the two groups (p = 0.09). Platelet count was statistically significantly higher in the calcified plaque group compared to the non-calcified plaque group (platelet count in calcified/non-calcified plaque groups [10(3)/mm(3)]: 250 +/- 63/226 +/- 56, respectively) (p = 0.019). Multivariate regression analysis showed that MPV was independently associated with non-calcified carotid artery plaque (odds ratio 5.95, 95% confidence interval 2.63-13.45, p < 0.001). Conclusions: Mean platelet volume is increased in the presence of non-calcified carotid artery plaques that cause asymptomatic intermediate stenosis. Increased MPV can be used as a marker to predict the risk of rupture of the non-calcified carotid artery plaques.
dc.identifier.citationYılmaz, F., Köklü, E., Kızılırmak Yılmaz, F., Sarıönder Gençer, E., Alparslan, A. Ş. ve Yıldırımtürk, Ö. (2017). Evaluation of mean platelet volume and platelet distribution width in patients with asymptomatic intermediate carotid artery plaque. Kardiologia Polska, 75(1), 35-41. https://dx.doi.org/10.5603/KP.a2016.0129
dc.identifier.doi10.5603/KP.a2016.0129
dc.identifier.endpage41
dc.identifier.issn0022-9032
dc.identifier.issn1897-4279
dc.identifier.issue1
dc.identifier.scopusqualityQ3
dc.identifier.startpage35
dc.identifier.urihttps://dx.doi.org/10.5603/KP.a2016.0129
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3355
dc.identifier.volume75
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVia Medica
dc.relation.ispartofKardiologia Polskaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAtherosclerosis
dc.subjectCarotid Artery Stenosis
dc.subjectMean Platelet Volume
dc.subjectPlatelet Distribution Width
dc.subjectNon-Calcified Plaque
dc.subjectStroke
dc.titleEvaluation of mean platelet volume and platelet distribution width in patients with asymptomatic intermediate carotid artery plaque
dc.typeArticle

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