Evaluation of treatment outcomes and tolerability in older patients with rectal cancer treated with radiotherapy accompanied by the G-8 geriatric score: TROD13–003 multicenter study

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dc.authorid0000-0001-5355-6609
dc.contributor.authorGüzelöz, Zeliha
dc.contributor.authorGörken, İlknur Bilkay
dc.contributor.authorAydın, Barbaros
dc.contributor.authorSert, Fatma
dc.contributor.authorYalman, Deniz
dc.contributor.authorParvizi, Murtaza
dc.contributor.authorAvcı, Gülhan Güler
dc.contributor.authorAltınok, Pelin
dc.contributor.authorHalis, Hatice
dc.contributor.authorErgen, Şefika Arzu
dc.contributor.authorAkgün, Züleyha
dc.contributor.authorÖzkan, Elif
dc.contributor.authorGüney, Yıldız
dc.contributor.authorKaraçetin, Didem
dc.contributor.authorKaydıhan, Nuri
dc.contributor.authorDüzova, Mürsel
dc.contributor.authorAkın, Murat
dc.contributor.authorUysal, Bora
dc.contributor.authorErdoğan, Mihriban
dc.contributor.authorEllidokuz, Hülya
dc.contributor.authorAksu, Gamze
dc.contributor.authorMetcalfe, Evrim
dc.date.accessioned2024-04-19T13:23:48Z
dc.date.available2024-04-19T13:23:48Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyasyon Onkolojisi Ana Bilim Dalı
dc.description.abstractIntroduction: The choice of treatment for rectal cancer often differs in older and younger patients, with the rate of radiotherapy use lower among older adults. In our daily practice, when evaluating a frail older patient with rectal cancer, we usually choose to give less treatment. This may be due to concern that the patient will not be able to tolerate radiotherapy. The Geriatric 8 score (G8GS) is a guide to evaluating treatment tolerability as it relates to frailty in older adults with cancer. The aim of this study was to evaluate treatment outcomes and tolerability in older patients with rectal cancer treated with radiotherapy (RT) accompanied by G8GS. Materials and Methods: Patients aged 65 and older with stage I-III rectal adenocarcinoma who were treated with RT and had a G8 evaluation were included in this multicenter retrospective study. Prognostic factors related to G8GS were calculated using Chi-square and logistic regression tests and survival rates were calculated by the Kaplan–Meier test using the SPSS v24.0 software. All p-values ?0.05 were considered statistically significant. Results: A total of 699 patients from 16 national institutions were evaluated. The median age was 72 years (range 65–96), and the median follow-up was 43 (range 1- 190) months. Four hundred and fifty patients (64%) were categorized as frail with G8GS ?14 points. Frail patients had higher ages (p = 0.001) and more comorbidities (p = 0.001). Ability to receive concomitant and/or adjuvant chemotherapy rates were significantly higher in fit patients (p = 0.002 and p = 0.001, respectively). No significant difference was observed in terms of grade 3-4 early and late toxicity for both groups. Cancer-related death was higher (p = 0.003), and 5- and 8-year survival rates were significantly lower (p = 0.001), in the frail group. Age and being frail were significantly associated with survival.
dc.identifier.citationGüzelöz, Z., Görken, İ. B., Aydın, B. Sert, F., Yalman, D., Parvizi, M. ... Metcalfe, E. (2024). Evaluation of treatment outcomes and tolerability in older patients with rectal cancer treated with radiotherapy accompanied by the G-8 geriatric score: TROD13–003 multicenter study. Journal of Geriatric Oncology, (15)3. http://dx.doi.org/10.1016/j.jgo.2024.101739
dc.identifier.doi10.1016/j.jgo.2024.101739
dc.identifier.issn1879-4068
dc.identifier.issue3
dc.identifier.pmid38492350
dc.identifier.scopus2-s2.0-85187997936
dc.identifier.scopusqualityQ2
dc.identifier.urihttp://dx.doi.org/10.1016/j.jgo.2024.101739
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12418
dc.identifier.volume15
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMetcalfe, Evrim
dc.language.isoen
dc.relation.ispartofJournal of Geriatric Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCapecitabine
dc.subjectFluorouracil
dc.subjectBiological Marker
dc.subjectAdjuvant Chemotherapy
dc.subjectAdjuvant Therapy
dc.subjectAge Distribution
dc.subjectAged
dc.subjectArticle
dc.subjectCancer Mortality
dc.subjectCancer Patient
dc.subjectCancer Prognosis
dc.subjectCancer Radiotherapy
dc.subjectCancer Staging
dc.subjectCancer Survival
dc.subjectChi Square Test
dc.subjectClinical Outcome
dc.subjectCohort Analysis
dc.subjectComorbidity
dc.subjectConformal Radiotherapy
dc.subjectControlled Study
dc.subjectEvaluation Research
dc.subjectFemale
dc.subjectFitness
dc.subjectFollow Up
dc.subjectFrail Elderly
dc.subjectG 8 Geriatric Score
dc.subjectGeriatric Assessment
dc.subjectHuman
dc.subjectKaplan Meier Method
dc.subjectLocal Recurrence Free Survival
dc.subjectLogistic Regression Analysis
dc.subjectMajor Clinical Study
dc.subjectMale
dc.subjectMetastasis Free Survival
dc.subjectMulticenter Study (Topic)
dc.subjectOverall Survival
dc.subjectPatient Coding
dc.subjectPatient Selection
dc.subjectProctitis
dc.subjectPrognostic Assessment
dc.subjectRadiation Toxicity
dc.subjectRectal Adenocarcinoma
dc.subjectRectum Cancer
dc.subjectRetrospective Study
dc.subjectStatistical Significance
dc.subjectSurvival Rate
dc.subjectTherapy
dc.subjectTreatment Outcome
dc.subjectTreatment Tolerability
dc.subjectVery Elderly
dc.subjectVolumetric Modulated Arc Therapy
dc.subjectAdult
dc.subjectData Analysis Software
dc.subjectDrug Therapy
dc.subjectFrailty
dc.subjectGeriatric Assessment
dc.subjectRadiotherapy
dc.subjectRectal Adenocarcinoma
dc.subjectRectum Cancer
dc.subjectSpecial Situation For Pharmacovigilance
dc.subjectTherapy Effect
dc.titleEvaluation of treatment outcomes and tolerability in older patients with rectal cancer treated with radiotherapy accompanied by the G-8 geriatric score: TROD13–003 multicenter study
dc.typeArticle

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