Nanoparticle-mediated histotripsy (NMH) using perfluorohexane 'nanocones'

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dc.authorid0000-0002-4634-3864
dc.authorid0000-0002-8548-6104
dc.authorid0000-0003-2776-5807
dc.contributor.authorKhirallah, Jennifer
dc.contributor.authorSchmieley, Rebecca
dc.contributor.authorDemirel, Erhan
dc.contributor.authorUr Rehman, Tanzeel
dc.contributor.authorHowell, Justin
dc.contributor.authorYüksel Durmaz, Yasemin
dc.contributor.authorVlaisavljevich, Eli
dc.date.accessioned2019-12-24T08:29:32Z
dc.date.available2019-12-24T08:29:32Z
dc.date.issued2019
dc.departmentİstanbul Medipol Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümü
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)
dc.description.abstractNanoparticle-mediated histotripsy (NMH) is an ultrasound treatment strategy that combines acoustically sensitive nanoparticles with histotripsy. Previous NMH studies using perfluorocarbon (PFC) nanodroplets (ND's), ?200 nm in diameter, demonstrated that NMH can selectively generate cavitation by reducing the cavitation threshold from ?25-30 MPa to ?10-15 MPa. Recent studies have also shown that cavitation nucleation in NMH is directly caused by the incident negative pressure (p-) exposed to the PFC, as predicted by classical nucleation theory (CNT), suggesting that the NMH cavitation threshold is dependent on the total volume of PFC present in the focal region. In this study, we investigate the use of a newly developed NMH nanoparticle synthesized using an inclusion complex of methylated ?-cyclodextrin and perfluorohexane (PFH). These 'nanocones' (NCs) have advantages compared to previously used ND's due to their smaller size (?50 nm), simple synthesis method, higher stability and information of definite PFH amount carried by the NC. To test the hypothesis that NCs can reduce the NMH cavitation threshold similar to ND's, and that the NMH cavitation threshold is dependent upon the total PFH concentration, tissue phantoms containing concentrations of NCs ranging from 10-5 to 10-10 (ml PFH/ml water) were exposed to single cycle ultrasound pulses using a 500 kHz focused transducer where high speed imaging captured cavitation data. Results showed that NCs significantly reduced the histotripsy cavitation threshold to 11.0 MPa for a concentration of 10-5 (ml PFH/ml water), with the threshold increasing at lower concentrations. Finally, the ability of NCs to be used for effective NMH ablation was demonstrated in tissue phantoms containing red blood cells (RBCs). Overall, the results of the study support our hypotheses that NCs can be used for effective NMH therapy and that NC concentration has a predictable threshold-reducing effect.
dc.description.sponsorshipVirginia Tech Department of Biomedical Engineering and Mechanicsen_US
dc.description.sponsorshipInstitute for Critical Technology and Applied Scienceen_US
dc.description.sponsorshipCenter for Engineering Healthen_US
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştırma Kurumu (TUBITAK)en_US
dc.description.sponsorshipTurkish Academy of Sciences (TUBA) through its Outstanding Young Scientist Award Program (TUBA-GEBIP)en_US
dc.identifier.citationKhirallah, J., Schmieley, R., Demirel, E., Ur Rehman, T., Howell, J., Yüksel Durmaz, Y. ... Vlaisavljevich, E. (2019). Nanoparticle-mediated histotripsy (NMH) using perfluorohexane 'nanocones'. Physics in Medicine and Biology, 64(12). https://doi.org/10.1088/1361-6560/ab207e
dc.identifier.doi10.1088/1361-6560/ab207e
dc.identifier.issn0031-9155
dc.identifier.issn1361-6560
dc.identifier.issue12
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1088/1361-6560/ab207e
dc.identifier.urihttps://hdl.handle.net/20.500.12511/4640
dc.identifier.volume64
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInstitute of Physics Publishing
dc.relation.ecinfo:eu-repo/grantAgreement/TUBITAK/SOBAG/118Z324
dc.relation.ispartofPhysics in Medicine and Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCavitation
dc.subjectHistotripsy
dc.subjectNanoparticle
dc.subjectNanoparticle-Mediated Histotripsy
dc.subjectUltrasound
dc.titleNanoparticle-mediated histotripsy (NMH) using perfluorohexane 'nanocones'
dc.typeArticle

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