The effect of hysteroscopic polypectomy on the gene expression of endometrial receptivity markers: HOXA10, HOXA11 and LIF

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dc.contributor.authorYıldırım, Engin
dc.contributor.authorÇelik, Önder
dc.contributor.authorAkgöz, Müslüm
dc.contributor.authorAksoy, İlknur
dc.contributor.authorTürkan, Ali
dc.contributor.authorKaraca, Zeynel Mete
dc.contributor.authorÇiğremiş, Yılmaz
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:27Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:27Z
dc.date.issued2014
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Laboratuvar Teknikleri Ana Bilim Dalı
dc.description.abstractThe aim of this study is to determine the effect of hysteroscopic polypectomy on the mRNA expression levels of the endometrial receptivity markers, namely, homeobox A10 (HOXA10), homeobox A11 (HOXA11) and leukemia inhibitory factor (LIF). Twenty-five reproductive-aged women with endometrial polyps underwent hysteroscopy. Samples were taken at the mid-secretory phase using hysteroscopic polypectomy and 4 months after polypectomy, and the change in mRNA expression levels of normalized HOXA10, HOXA11 and LIF genes were determined using Reverse Transcription Quantitative Real Time-Polymerase Chain Reaction (RT-qPCR). The results show that mRNA levels of HOXA10 and HOXA11 taken prior to surgery and 4 months after the complete hysteroscopic removal of polyps were not significantly different (P=0.79 and P=0.14, respectively). Moreover, a marked difference could not be obtained between preoperative and postoperative endometrial LIF mRNA expression levels (P=0.86). As a conclusion, these results indicate that mRNA levels of HOXA10, HOXA11 and LIF genes, three of molecular markers of endometrial receptivity, are not affected by hysteroscopic polypectomy.
dc.identifier.citationYıldırım, E., Çelik, Ö., Akgöz, M., Yurtsever Aksoy, İ., Türkan, A., Karaca, Z. M. ve Çiğmemiş, Y. (2014). The effect of hysteroscopic polypectomy on the gene expression of endometrial receptivity markers: HOXA10, HOXA11 and LIF. Gene Therapy and Molecular Biology, 16(1), 95-104.
dc.identifier.endpage104
dc.identifier.issn1529-9120
dc.identifier.issue1
dc.identifier.scopusqualityQ4
dc.identifier.startpage95
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1167
dc.identifier.volume16
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherGene Therapy and Molecular Biology
dc.relation.ispartofGene Therapy and Molecular Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEndometrialpolyp
dc.subjectHomeobox A10
dc.subjectHomeobox A11
dc.subjectHoxa10
dc.subjectHOXA11 and LIF
dc.subjectRT-qPCR
dc.titleThe effect of hysteroscopic polypectomy on the gene expression of endometrial receptivity markers: HOXA10, HOXA11 and LIF
dc.typeArticle

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