Possible effects of neonatal vitamin B12 status on TSH-screening program: A cross-sectional study from Turkey

Basit Öğe Kaydı
dc.authorid0000-0003-4930-8447
dc.contributor.authorÖnal, Zerrin
dc.contributor.authorBalkaya, Seda
dc.contributor.authorErsen, Atilla
dc.contributor.authorMutlu, Neval
dc.contributor.authorÖnal, Hasan
dc.contributor.authorAdal, Erdal
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T20:01:26Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T20:01:26Z
dc.date.issued2017
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.descriptionWOS: 000400461100008
dc.descriptionPubMed ID: 28350538
dc.description.abstractBackground: In this study we evaluated whether vitamin B12 deficiency affects neonatal screening (NS) for congenital hypothyroidism (CH). Methods: A cross-sectional study conducted from 2010 to 2011. A total of 10,740 infants were born in our hospital in this period. Thyroid-stimulating hormone (TSH) was tested for NS and neonates with abnormal screening results (TSH > 20 mIU/L) were re-examined. Two hundred and twenty-nine re-called subjects (re-call rate 2.3%) were compared to 77 randomly selected newborns with normal TSH screening among these term newborns in terms of serum TSH, free T4, vitamin B12 and homocysteine status. Results: Of the 229 re-called subjects, 11 infants with CH and 21 infants with transient TSH elevation were detected. In the normal TSH screening group, only two infants were diagnosed with transient TSH elevation. Mean serum B12 levels were 126.4 +/- 48.7 pg/mL and 211.9 +/- 127.9 pg/mL in the positive TSH-screening group and the control group, respectively. There was a significant difference between positive and normal TSH-screening groups in regard to serum TSH, free T4, serum B12 and homocysteine levels. Conclusions: We found a significant vitamin B12 deficiency in positive TSH-screening infants. Beside the crucial role of vitamin B12 in newborns, deficiency seems to increase the recall rates of infants in an NS program for CH.
dc.identifier.citationÖnal, Z., Balkaya, S., Ersen, A., Mutlu, N., Önal, H. ve Adal, E. (2017). Possible effects of neonatal vitamin B12 status on TSH-screening program: A cross-sectional study from Turkey. Journal of Pediatric Endocrinology & Metabolism, 30(5), 551-555. https://dx.doi.org/10.1515/jpem-2016-0066
dc.identifier.doi10.1515/jpem-2016-0066
dc.identifier.endpage555
dc.identifier.issn0334-018X
dc.identifier.issn2191-0251
dc.identifier.issue5
dc.identifier.scopusqualityQ3
dc.identifier.startpage551
dc.identifier.urihttps://dx.doi.org/10.1515/jpem-2016-0066
dc.identifier.urihttps://hdl.handle.net/20.500.12511/3270
dc.identifier.volume30
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWalter de Gruyter GMBH
dc.relation.ispartofJournal of Pediatric Endocrinology & Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCongenital Hypothyroidism
dc.subjectNewborn
dc.subjectScreening Program
dc.subjectVitamin B12
dc.titlePossible effects of neonatal vitamin B12 status on TSH-screening program: A cross-sectional study from Turkey
dc.typeArticle

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu