Prospective analysis of febrile neutropenia patients with bacteraemia: The results of an international ID-IRI study

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dc.authorid0000-0001-8022-7325
dc.authorid0000-0001-8930-741X
dc.contributor.authorErdem, Hakan
dc.contributor.authorKoçoğlu, Esra
dc.contributor.authorAnkaralı, Handan
dc.contributor.authorEl-Sokkary, Rehab
dc.contributor.authorHakamifard, Atousa
dc.contributor.authorKaraali, Rıdvan
dc.contributor.authorKulzhanova, Sholpan
dc.contributor.authorSirmatel, Fatma
dc.date.accessioned2023-09-11T11:11:25Z
dc.date.available2023-09-11T11:11:25Z
dc.date.issued2023
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractOBJECTIVES: Bacteraemia during the course of neutropenia is often fatal. We aimed to identify factors predicting mortality to have an insight into better clinical management. METHODS: The study has a prospective, observational design using pooled data from febrile neutropenia patients with bacteraemia in 41 centres in 16 countries. Polymicrobial bacteraemias were excluded. It was performed through the Infectious Diseases-International Research Initiative platform between 17 March 2021 and June 2021. Univariate analysis followed by a multivariate binary logistic regression model was used to determine independent predictors of 30-d in-hospital mortality (sensitivity, 81.2%; specificity, 65%). RESULTS: A total of 431 patients were enrolled, and 85 (19.7%) died. Haematological malignancies were detected in 361 (83.7%) patients. Escherichia coli (n = 117, 27.1%), Klebsiellae (n = 95, 22% %), Pseudomonadaceae (n = 63, 14.6%), Coagulase-negative Staphylococci (n = 57, 13.2%), Staphylococcus aureus (n = 30, 7%), and Enterococci (n = 21, 4.9%) were the common pathogens. Meropenem and piperacillin-tazobactam susceptibility, among the isolated pathogens, were only 66.1% and 53.6%, respectively. Pulse rate (odds ratio [OR], 1.018; 95% confidence interval [CI], 1.002-1.034), quick SOFA score (OR, 2.857; 95% CI, 2.120-3.851), inappropriate antimicrobial treatment (OR, 1.774; 95% CI, 1.011-3.851), Gram-negative bacteraemia (OR, 2.894; 95% CI, 1.437-5.825), bacteraemia of non-urinary origin (OR, 11.262; 95% CI, 1.368-92.720), and advancing age (OR, 1.017; 95% CI, 1.001-1.034) were independent predictors of mortality. Bacteraemia in our neutropenic patient population had distinctive characteristics. The severity of infection and the way to control it with appropriate antimicrobials, and local epidemiological data, came forward. CONCLUSIONS: Local antibiotic susceptibility profiles should be integrated into therapeutic recommendations, and infection control and prevention measures should be prioritised in this era of rapidly increasing antibiotic resistance.
dc.identifier.citationErdem, H., Koçoğlu, E., Ankaralı, H., El-Sokkary, R., Hakamifard, A., Karaali, R. ... Sirmatel, F. (2023). Prospective analysis of febrile neutropenia patients with bacteraemia: The results of an international ID-IRI study. International Journal of Antimicrobial Agents, 62(3), 106919-106919. https://dx.doi.org/10.1016/j.ijantimicag.2023.106919
dc.identifier.doi10.1016/j.ijantimicag.2023.106919
dc.identifier.endpage106919
dc.identifier.issn1872-7913
dc.identifier.issue3
dc.identifier.pmid37423582
dc.identifier.scopus2-s2.0-85168807565
dc.identifier.scopusqualityQ1
dc.identifier.startpage106919
dc.identifier.urihttps://dx.doi.org/10.1016/j.ijantimicag.2023.106919
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11404
dc.identifier.volume62
dc.identifier.wos001063127400001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYılmaz, Mesut
dc.institutionauthorÇakmak, Rümeysa
dc.language.isoen
dc.publisherNLM (Medline)
dc.relation.ispartofInternational Journal of Antimicrobial Agentsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAntibiotic Stewardship
dc.subjectAntimicrobial
dc.subjectBacteraemia
dc.subjectFebrile Neutropenia
dc.subjectResistance
dc.titleProspective analysis of febrile neutropenia patients with bacteraemia: The results of an international ID-IRI study
dc.typeArticle

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