Amoxicillin loaded hollow microparticles in the treatment of osteomyelitis disease using single-nozzle electrospinning

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dc.authorid0000-0002-0368-4028
dc.contributor.authorAltun, Esra
dc.contributor.authorAydoğdu, Mehmet Onur
dc.contributor.authorKoç, Fatma
dc.contributor.authorKutlu, Özlem
dc.contributor.authorGözüaçık, Devrim
dc.contributor.authorYücel, Sevil
dc.contributor.authorGündüz, Oğuzhan
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:50:15Z
dc.date.available10.07.201910:49:13
dc.date.available2019-07-10T19:50:15Z
dc.date.issued2018
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.descriptionWOS: 000444750500009
dc.description.abstractIn this study, hollow microparticles were produced with polymethylsilsesquioxane/chitosan/bovine hydroxyapatite/hexagonalboron nitride (PCBB) polyblend using single-nozzle electrospinning method. Also, hollow microparticles are loaded withamoxicillin (AMX) and their drug delivery capabilities have been studied according to a treatment of osteomyelitis disease.The morphology, chemical groups, particle size, antimicrobial activity, and AMX drug release were systematically studied usingscanning electron microscopy (SEM), optical microscopy, Fourier transformation infrared spectroscopy (FTIR), hollow microparticle size measurements, antimicrobial activity test, and UV spectroscopy. In vitro biocompatibility was analyzed with humanbone osteosarcoma (U2OS) cell line. This present work can help in the design of a drug delivery platform for antimicrobial effectand bone repair at the same time for osteomyelitis disease treatment.
dc.identifier.citationAltun, E., Aydoğdu, M. O., Koç, F., Kutlu, Ö., Gözüaçık, D., Yücel, S. ... Gündüz, O. (2018). Amoxicillin loaded hollow microparticles in the treatment of osteomyelitis disease using single-nozzle electrospinning. Bionanoscience, 8(3), 790-801. https://dx.doi.org/10.1007/s12668-018-0539-y
dc.identifier.doi10.1007/s12668-018-0539-y
dc.identifier.endpage801
dc.identifier.issn2191-1630
dc.identifier.issn2191-1649
dc.identifier.issue3
dc.identifier.scopusqualityQ4
dc.identifier.startpage790
dc.identifier.urihttps://dx.doi.org/10.1007/s12668-018-0539-y
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1930
dc.identifier.volume8
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofBionanoscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSingle-Nozzle Electrospinning
dc.subjectHollow Microparticles
dc.subjectOsteomyelitis
dc.subjectDrug Delivery
dc.subjectBone Tissue Engineering
dc.titleAmoxicillin loaded hollow microparticles in the treatment of osteomyelitis disease using single-nozzle electrospinning
dc.typeArticle

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