Investigation of the cytotoxic effect of current dentine bonding agents on human dental pulp cells

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dc.contributor.authorKoruyucu, Mine
dc.contributor.authorAkay, Cansu
dc.contributor.authorSolakoğlu, Seyhun
dc.contributor.authorGencay, Koray
dc.date.accessioned2025-10-22T09:50:34Z
dc.date.available2025-10-22T09:50:34Z
dc.date.issued2024
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractBackground: An ideal aesthetic restorative material should be attached to the tooth tissues by adhesion, have a smooth surface as possible, should not cause toxic reactions in the pulp and discoloration and microleakage. This study aims at comparatively assess the cytotoxicity of current adhesive systems on human dental pulp cells. Materials and methods: The adequate density of human pulp cells was observed from the ready cell line. The passaging was performed and the 3rd passage cells were selected. Adhesive systems and MTA were used on the cultures. Trypan blue staining was conducted on the cells at the 1st, 2nd, 3rd days and a count of live and dead cells using a light microscope. The dead cells whose membrane integrity was impaired by staining with trypan blue and the viability rate was determined using live and dead cell numbers. Data analysis was performed using IBM SPSS Statistics 22. Results: A significant difference in vialibity rates between adhesive systems was observed on the first day. No significant statistical differences were observed on the 2nd and 3rd days (p < 0.05). Conclusion: Futurabond M showed similar biocompatibility with MTA on human pulp cells and it can be applied in cavities with 1–1.5 mm hard tissue between pulp and dentine.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul University
dc.identifier.citationKoruyucu, M., Akay, C., Solakoğlu, S. ve Gencay, K. (2024). Investigation of the cytotoxic effect of current dentine bonding agents on human dental pulp cells. BMC Oral Health, 24(1). http://dx.doi.org/10.1186/s12903-024-04985-1
dc.identifier.doi10.1186/s12903-024-04985-1
dc.identifier.issn1472-6831
dc.identifier.issue1
dc.identifier.pmid39390415
dc.identifier.scopus2-s2.0-85206049672
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://dx.doi.org/10.1186/s12903-024-04985-1
dc.identifier.urihttps://hdl.handle.net/20.500.12511/13134
dc.identifier.volume24
dc.identifier.wosWOS:001336903600003
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkay, Cansu
dc.institutionauthorSolakoğlu, Seyhun
dc.institutionauthorid0000-0002-3158-9300
dc.language.isoen
dc.relation.ecinfo:eu-repo/grantAgreement/EC/FP7/32787
dc.relation.ispartofBMC Oral Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectBonding Agents
dc.subjectCell Viability
dc.subjectDental Pulp
dc.subjectStem Cell
dc.titleInvestigation of the cytotoxic effect of current dentine bonding agents on human dental pulp cells
dc.typeArticle

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